DCTA_XANCP
ID DCTA_XANCP Reviewed; 448 AA.
AC Q8P5J5;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=C4-dicarboxylate transport protein {ECO:0000255|HAMAP-Rule:MF_01300};
GN Name=dctA {ECO:0000255|HAMAP-Rule:MF_01300}; OrderedLocusNames=XCC3346;
OS Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB
OS 528 / LMG 568 / P 25).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Xanthomonas.
OX NCBI_TaxID=190485;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25;
RX PubMed=12024217; DOI=10.1038/417459a;
RA da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R.,
RA Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr.,
RA Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G.,
RA Cannavan F., Cardozo J., Chambergo F., Ciapina L.P., Cicarelli R.M.B.,
RA Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B.,
RA Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F.,
RA Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T.,
RA Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A.,
RA Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J.,
RA Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M.,
RA Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A.,
RA Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A.,
RA Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M.,
RA Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P.;
RT "Comparison of the genomes of two Xanthomonas pathogens with differing host
RT specificities.";
RL Nature 417:459-463(2002).
CC -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC succinate, fumarate, and malate from the periplasm across the membrane.
CC {ECO:0000255|HAMAP-Rule:MF_01300}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01300}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01300}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000255|HAMAP-Rule:MF_01300}.
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DR EMBL; AE008922; AAM42616.1; -; Genomic_DNA.
DR RefSeq; NP_638692.1; NC_003902.1.
DR RefSeq; WP_011038444.1; NC_003902.1.
DR AlphaFoldDB; Q8P5J5; -.
DR SMR; Q8P5J5; -.
DR STRING; 340.xcc-b100_0852; -.
DR EnsemblBacteria; AAM42616; AAM42616; XCC3346.
DR GeneID; 58012122; -.
DR KEGG; xcc:XCC3346; -.
DR PATRIC; fig|190485.4.peg.3578; -.
DR eggNOG; COG1301; Bacteria.
DR HOGENOM; CLU_019375_7_0_6; -.
DR OMA; QATNTPM; -.
DR Proteomes; UP000001010; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015138; F:fumarate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015366; F:malate:proton symporter activity; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0070778; P:L-aspartate transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.3860.10; -; 1.
DR HAMAP; MF_01300; C4_dicarb_transport; 1.
DR InterPro; IPR023954; C4_dicarb_transport.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865; PTHR42865; 1.
DR Pfam; PF00375; SDF; 1.
DR SUPFAM; SSF118215; SSF118215; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..448
FT /note="C4-dicarboxylate transport protein"
FT /id="PRO_0000202114"
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 51..73
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 138..157
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 161..178
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 198..220
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 230..252
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT REGION 428..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 448 AA; 47406 MW; 42A5B1F97836F279 CRC64;
MHISKPAGPL PAPVPFYRQL YFQVVVAIVL GALLGHFEPA FAESLKPLGD AFIKLVKMII
APVIFLTIVT GIAGMTHLKT VGRVFAKSMT YFLFFSTLAL IVGMVVAHVV QPGAGMNINP
AELDQSAVNT YVQKSHELSL VGFLMDIIPA TLISAFVDGN ILQVLFVAVL FGIALALVGE
RGRPVLSFLE ALTAPVFRLV HMLMKAAPIG AFGAIAFTIG KYGVESLVNL AWLVGSFYLT
SLFFVLVILG IVCRLCGFSV LKLIRYLKAE LLLVLGTSSS ESALPSLMEK MEKAGCEKSV
VGLVVPTGYS FNLDGTNIYM TLAALFIAQA TNVDLTLGQQ ITLLAVAMLS SKGAAGVTGA
GFITLAATLS VVPDVPVAGM ALILGVDRFM SECRSLTNFI GNAVATVVVS RWENALDRDQ
LSLALDGRAP PLQAPVPPPD AVAPVSAR
