DCTB_BACSU
ID DCTB_BACSU Reviewed; 350 AA.
AC P96600; Q797L6;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=C4-dicarboxylate-binding protein DctB;
DE Flags: Precursor;
GN Name=dctB; Synonyms=ydbE; OrderedLocusNames=BSU04440;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT subtilis genome.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION.
RX PubMed=10708364; DOI=10.1099/00221287-146-2-263;
RA Asai K., Baik S.-H., Kasahara Y., Moriya S., Ogasawara N.;
RT "Regulation of the transport system for C4-dicarboxylic acids in Bacillus
RT subtilis.";
RL Microbiology 146:263-271(2000).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC uptake of C4-dicarboxylates. Responsible for growth on fumarate and
CC succinate but not malate. Is not directly involved in C4-dicarboxylate
CC uptake, but plays a sensory role in the DctS/DctR two-component system
CC which regulates the expression of the dctA C4-dicarboxylate
CC transporter. {ECO:0000269|PubMed:10708364}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 7 family.
CC {ECO:0000305}.
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DR EMBL; AB001488; BAA19281.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12251.1; -; Genomic_DNA.
DR PIR; H69770; H69770.
DR RefSeq; NP_388325.1; NC_000964.3.
DR RefSeq; WP_003234350.1; NZ_JNCM01000031.1.
DR AlphaFoldDB; P96600; -.
DR SMR; P96600; -.
DR STRING; 224308.BSU04440; -.
DR PaxDb; P96600; -.
DR PRIDE; P96600; -.
DR EnsemblBacteria; CAB12251; CAB12251; BSU_04440.
DR GeneID; 938226; -.
DR KEGG; bsu:BSU04440; -.
DR PATRIC; fig|224308.179.peg.470; -.
DR eggNOG; COG1638; Bacteria.
DR InParanoid; P96600; -.
DR OMA; FRIMPSE; -.
DR PhylomeDB; P96600; -.
DR BioCyc; BSUB:BSU04440-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 3.40.190.170; -; 1.
DR InterPro; IPR018389; DctP_fam.
DR InterPro; IPR004682; TRAP_DctP.
DR InterPro; IPR038404; TRAP_DctP_sf.
DR PANTHER; PTHR33376; PTHR33376; 1.
DR Pfam; PF03480; DctP; 1.
DR PIRSF; PIRSF006470; DctB; 1.
DR TIGRFAMs; TIGR00787; dctP; 1.
PE 3: Inferred from homology;
KW Reference proteome; Secreted; Signal; Sugar transport; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..350
FT /note="C4-dicarboxylate-binding protein DctB"
FT /id="PRO_0000360643"
SQ SEQUENCE 350 AA; 39862 MW; 25F40C93E20E0E24 CRC64;
MKSLLACLAL MIAGIATALF IGFHDHTGNK KIVYDDDQEG LQDQIVFKFS HVVAENTPKG
LAANKFADLV NEKSGGKIKI EVFPNGSLYS DIEEIEALQN GDVQFIAPST SKLGMLSPEW
GVLDLPYAFT DYNAVKKGLN GSIGTQLFDS LKKNQLKGLA YWTNGFKQIT TNQGPVKTPD
DLKGQDLRIM QSDVIEDQFK LLGATPHQES FNSTFQLLEN NVVDGEENTI SNIYSKKFYN
VQDYLTISSH GYLGYAVMTD EHFWKAQTPE TRRILTEAMK ETTEWNETYA EQMNKEQLEE
IKKNSAIHIY ELSDKEKQEW MKRLDPVYRQ YEPIFGRELI RELLELRKDS
