DCTD_PSEAE
ID DCTD_PSEAE Reviewed; 462 AA.
AC Q9HU19;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=C4-dicarboxylate transport transcriptional regulatory protein DctD {ECO:0000305};
GN Name=dctD {ECO:0000303|PubMed:21725012};
GN OrderedLocusNames=PA5166 {ECO:0000312|EMBL:AAG08551.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2]
RP FUNCTION.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=21725012; DOI=10.1128/jb.05074-11;
RA Valentini M., Storelli N., Lapouge K.;
RT "Identification of C(4)-dicarboxylate transport systems in Pseudomonas
RT aeruginosa PAO1.";
RL J. Bacteriol. 193:4307-4316(2011).
CC -!- FUNCTION: Member of the two-component regulatory system DctB/DctD,
CC which regulates C4-dicarboxylate transport via regulation of expression
CC of the dctPQM operon and dctA. {ECO:0000269|PubMed:21725012}.
CC -!- PTM: Phosphorylated by DctB. {ECO:0000250|UniProtKB:P13632}.
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DR EMBL; AE004091; AAG08551.1; -; Genomic_DNA.
DR PIR; G83000; G83000.
DR RefSeq; NP_253853.1; NC_002516.2.
DR RefSeq; WP_003096187.1; NZ_QZGE01000002.1.
DR AlphaFoldDB; Q9HU19; -.
DR SMR; Q9HU19; -.
DR STRING; 287.DR97_2534; -.
DR PaxDb; Q9HU19; -.
DR PRIDE; Q9HU19; -.
DR EnsemblBacteria; AAG08551; AAG08551; PA5166.
DR GeneID; 879963; -.
DR KEGG; pae:PA5166; -.
DR PATRIC; fig|208964.12.peg.5414; -.
DR PseudoCAP; PA5166; -.
DR HOGENOM; CLU_000445_0_5_6; -.
DR InParanoid; Q9HU19; -.
DR OMA; CATHQNL; -.
DR PhylomeDB; Q9HU19; -.
DR BioCyc; PAER208964:G1FZ6-5283-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0032892; P:positive regulation of organic acid transport; IMP:PseudoCAP.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR002197; HTH_Fis.
DR InterPro; IPR030828; HTH_TypR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR InterPro; IPR025944; Sigma_54_int_dom_CS.
DR Pfam; PF18024; HTH_50; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR PRINTS; PR01590; HTHFIS.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 3: Inferred from homology;
KW Activator; ATP-binding; DNA-binding; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1..462
FT /note="C4-dicarboxylate transport transcriptional
FT regulatory protein DctD"
FT /id="PRO_0000435377"
FT DOMAIN 12..126
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 152..381
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT BINDING 180..187
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT BINDING 243..252
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT MOD_RES 61
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 462 AA; 50865 MW; 981D88847B2BABBF CRC64;
MSPFAPFDAQ TQVLLIDDDP HLRQALRQTL DLAGLKVATL DDARQLDTAQ CKDWPGVVVS
DIRMPGIDGM ELLRQLHEQD ADLPVILITG HGDVPLAVQA MRGGAYDFLE KPFPSDALLD
SVRRALEVRR LVLENRTLRL ALAERHELHG RLIGRSAGMQ RLREQVGSLA AIQADVLVLG
ETGAGKEVVA RALHDLSSRR DGPFVAINAG ALAESVVESE LFGHEAGAFT GAQKRRIGKF
EYANGGTLFL DEIESMSLDV QVKLLRLLQE RVVERLGSNQ LIPLDIRIIA ATKEDLRQAA
DQGRFRADLY YRLNVASLRI PPLRERGEDI PLLFRHFAEA GAMRHGLTPR ELDAGQSARL
LAYDWPGNVR ELQNAAERFA LGLGLSLDDG VLPDAADEPH NLSAKVEAFE RSLIAAELER
PHNSLRSVAE ALGIPRKTLH DKLRKHGLPF NTPGENPPDD GE
