ID   DCTD_RHILE              Reviewed;         448 AA.
AC   P10046;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=C4-dicarboxylate transport transcriptional regulatory protein DctD;
GN   Name=dctD;
OS   Rhizobium leguminosarum.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=384;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3671068; DOI=10.1093/nar/15.19.7921;
RA   Ronson C.W., Astwood P.M., Nixon B.T., Ausubel F.M.;
RT   "Deduced products of C4-dicarboxylate transport regulatory genes of
RT   Rhizobium leguminosarum are homologous to nitrogen regulatory gene
RT   products.";
RL   Nucleic Acids Res. 15:7921-7934(1987).
CC   -!- FUNCTION: Member of the two-component regulatory system DctB/DctD
CC       involved in the transport of C4-dicarboxylates. When activated by DctB
CC       acts in conjunction with sigma-54 to activate the transcription of
CC       dctA.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by DctB.
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DR   EMBL; X06253; CAA29596.1; -; Genomic_DNA.
DR   EMBL; Z11529; CAA77620.1; -; Genomic_DNA.
DR   PIR; B26981; B26981.
DR   AlphaFoldDB; P10046; -.
DR   SMR; P10046; -.
DR   STRING; 936136.ARRT01000006_gene4360; -.
DR   eggNOG; COG2204; Bacteria.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR002197; HTH_Fis.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR002078; Sigma_54_int.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR   InterPro; IPR025944; Sigma_54_int_dom_CS.
DR   Pfam; PF02954; HTH_8; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00158; Sigma54_activat; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR   PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR   PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR   PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR   PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE   3: Inferred from homology;
KW   Activator; ATP-binding; Cytoplasm; DNA-binding; Nucleotide-binding;
KW   Phosphoprotein; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..448
FT                   /note="C4-dicarboxylate transport transcriptional
FT                   regulatory protein DctD"
FT                   /id="PRO_0000081088"
FT   DOMAIN          6..120
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          145..374
FT                   /note="Sigma-54 factor interaction"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   DNA_BIND        416..435
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   REGION          332..345
FT                   /note="Inter-domain linker"
FT                   /evidence="ECO:0000255"
FT   BINDING         173..180
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   BINDING         236..245
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   MOD_RES         55
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   448 AA;  49485 MW;  E4C0AB9592D41CAA CRC64;
     MDTLMPVALI DDDKDLRRAT AQTLELAGFS VSAYDGAKAA LADLPADFAG PVVTDIRMPE
     IDGLQLFATL QGMDVDLPVI LMTGHGDIPM AVQAIQDGAY DFIAKPFAAD RLVQSVRRAS
     EKRRLVLENR MLRKAAEDAQ ENLPLIGQTP VMENLRNILR HIADTDVDVL VAGETGSGKE
     VVAQILHQWS HRRKGNFVAL NCGALPETVI ESELFGHERG AFTGAQKRRT GRIEHASGGT
     LFLDEIESMP AATQVKMLRV LEMREITPLG TNEVRPVNLR VVAAAKIDLG DPAVRGDFRE
     DLYYRLNVVT ISIPPLRERR DDIPLLFSHF AARAAERFRR DVPPLSPDVR RHLASHTWPG
     NVRELSHYAE RVVLGVEGGG AAAVPPQPTG ATLPERLERY EAEIIRDTLS ANDGDVRRTI
     EALGIPRKTF YDKLQRHGIN RGGYSSRK