DCTM_VIBCH
ID DCTM_VIBCH Reviewed; 453 AA.
AC Q9KQS1;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=C4-dicarboxylate TRAP transporter large permease protein DctM {ECO:0000305};
GN Name=dctM {ECO:0000303|PubMed:22556361};
GN OrderedLocusNames=VC_1927 {ECO:0000312|EMBL:AAF95075.1};
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
RN [2]
RP PROBABLE FUNCTION.
RX PubMed=22556361; DOI=10.1099/mic.0.059659-0;
RA Chowdhury N., Norris J., McAlister E., Lau S.Y., Thomas G.H., Boyd E.F.;
RT "The VC1777-VC1779 proteins are members of a sialic acid-specific subfamily
RT of TRAP transporters (SiaPQM) and constitute the sole route of sialic acid
RT uptake in the human pathogen Vibrio cholerae.";
RL Microbiology 158:2158-2167(2012).
CC -!- FUNCTION: Part of the tripartite ATP-independent periplasmic (TRAP)
CC transport system DctPQM involved in C4-dicarboxylates uptake.
CC {ECO:0000305|PubMed:22556361}.
CC -!- SUBUNIT: The complex comprises the extracytoplasmic solute receptor
CC protein DctP, and the two transmembrane proteins DctQ and DctM.
CC {ECO:0000250|UniProtKB:O07838}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:O07838}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TRAP transporter large permease family.
CC {ECO:0000305}.
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DR EMBL; AE003852; AAF95075.1; -; Genomic_DNA.
DR PIR; D82140; D82140.
DR RefSeq; NP_231561.1; NC_002505.1.
DR RefSeq; WP_000257380.1; NZ_LT906614.1.
DR AlphaFoldDB; Q9KQS1; -.
DR STRING; 243277.VC_1927; -.
DR PRIDE; Q9KQS1; -.
DR DNASU; 2613556; -.
DR EnsemblBacteria; AAF95075; AAF95075; VC_1927.
DR GeneID; 57740558; -.
DR KEGG; vch:VC_1927; -.
DR PATRIC; fig|243277.26.peg.1844; -.
DR eggNOG; COG1593; Bacteria.
DR HOGENOM; CLU_019824_4_1_6; -.
DR OMA; IVVNMEV; -.
DR BioCyc; VCHO:VC1927-MON; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015740; P:C4-dicarboxylate transport; IBA:GO_Central.
DR InterPro; IPR010656; DctM.
DR InterPro; IPR004681; TRAP_DctM.
DR PANTHER; PTHR33362; PTHR33362; 1.
DR Pfam; PF06808; DctM; 1.
DR PIRSF; PIRSF006066; HI0050; 1.
DR TIGRFAMs; TIGR00786; dctM; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..453
FT /note="C4-dicarboxylate TRAP transporter large permease
FT protein DctM"
FT /id="PRO_0000435380"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 453 AA; 48081 MW; 415847B043D98335 CRC64;
MAVALLFILV IGMMIVGVPI AISLGLSSIL FLLWHSDASL ASVAQTLFNA FAGHYTLLAI
PFFILASTFM STGGVAKRII RFAIAMVGWF RGGLAIASVV ACMMFAALSG SSPATVVAIG
SIVIAGMVKN GYSKEFAAGV ICNAGTLGIL IPPSIVMVVY SAATNVSVGR MFLGGVVPGL
LAGLMLIIAI YITARIKNLP KQPFVGWKEA LKAAKEASWG LLLVVIILGG IYGGIFTPTE
AAAVAAVYSF FIANFIYRDM GPFADKTNTK PVLVKVVETF VHKDTKATLY DAGKLTIMLM
FIIANALILK HVLTEERIPQ MITESMLSAG LGPITFLIVV NLILLVGGQF MEPSGLLVIV
APLVFPIAIA LGIDPIHLGI MMVVNMEIGM ITPPVGLNLF VTSGVAKMSM MNVVKAALPW
VGVMFLFLII VTYVPWVSTW LPTLLMGPEI ITR
