ID   DCTN2_AEDAE             Reviewed;         381 AA.
AC   Q1HQF2; Q177T7;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Dynactin subunit 2;
DE   AltName: Full=Dynactin 2 p50 subunit {ECO:0000250|UniProtKB:Q7K2D2};
GN   Name=DCTN2-p50 {ECO:0000250|UniProtKB:Q7K2D2};
GN   Synonyms=Dmn {ECO:0000250|UniProtKB:Q7K2D2}; ORFNames=AAEL006029;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:ABF18525.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Black-eyed Liverpool; TISSUE=Salivary gland;
RX   PubMed=17204158; DOI=10.1186/1471-2164-8-6;
RA   Ribeiro J.M.C., Arca B., Lombardo F., Calvo E., Phan V.M., Chandra P.K.,
RA   Wikel S.K.;
RT   "An annotated catalogue of salivary gland transcripts in the adult female
RT   mosquito, Aedes aegypti.";
RL   BMC Genomics 8:6-6(2007).
RN   [2] {ECO:0000312|EMBL:EAT42431.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and
CC       plays a role in prometaphase chromosome alignment and spindle
CC       organization during mitosis. {ECO:0000250}.
CC   -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC       dynein. {ECO:0000250|UniProtKB:Q13561}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Membrane
CC       {ECO:0000250|UniProtKB:Q13561}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q13561}.
CC   -!- SIMILARITY: Belongs to the dynactin subunit 2 family. {ECO:0000255}.
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DR   EMBL; DQ440492; ABF18525.1; -; mRNA.
DR   EMBL; CH477371; EAT42431.1; -; Genomic_DNA.
DR   RefSeq; XP_001657375.1; XM_001657325.1.
DR   AlphaFoldDB; Q1HQF2; -.
DR   SMR; Q1HQF2; -.
DR   STRING; 7159.AAEL006029-PA; -.
DR   PRIDE; Q1HQF2; -.
DR   VEuPathDB; VectorBase:AAEL020113; -.
DR   eggNOG; KOG3958; Eukaryota.
DR   HOGENOM; CLU_049964_1_0_1; -.
DR   InParanoid; Q1HQF2; -.
DR   OMA; RGYDMRG; -.
DR   PhylomeDB; Q1HQF2; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005869; C:dynactin complex; ISS:UniProtKB.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
DR   GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR   InterPro; IPR028133; Dynamitin.
DR   PANTHER; PTHR15346; PTHR15346; 1.
DR   Pfam; PF04912; Dynamitin; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule;
KW   Reference proteome.
FT   CHAIN           1..381
FT                   /note="Dynactin subunit 2"
FT                   /id="PRO_0000306373"
FT   REGION          15..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          100..216
FT                   /evidence="ECO:0000255"
FT   COILED          350..381
FT                   /evidence="ECO:0000255"
FT   CONFLICT        183
FT                   /note="V -> G (in Ref. 1; ABF18525)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   381 AA;  42265 MW;  036EB005ED9D1F54 CRC64;
     MADPKFQFLP YIAHDQPDVY ETPDAPESET SDFYDEEPAN ESIERLHIST KDSYNKFKGK
     YLTGNVDFSD RIGKKIRNGY DAVSGEWDLA GEGEKETPIQ KCLRLQCEMN ELMEEITASQ
     ADATKTKEEK ASYEAVFDVV GTAKKVLESL KLEQAIGSET VAMGAETEAK KLLTKIEEYK
     KSVGADPAKT ATELVYSSRI AELEHRLHEL EVAVGAKPEK ISRLAGSAGA GNLIEAVQSI
     SAKAALLQPQ QLDLIETRLG NLLLKMAAID EKSAATGQDA NREQKILELY EIAKTTEPIV
     QILPDMLNRM QTLESLHKYA TNFSKLFAEL ETTQASILKG IASNKTLLTG VQEAFAQNLE
     NVNKEVKKLD ERMKTLQEKV K