ID   DCTN2_ANOGA             Reviewed;         387 AA.
AC   Q7PZ25;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Dynactin subunit 2;
DE   AltName: Full=Dynactin 2 p50 subunit {ECO:0000250|UniProtKB:Q7K2D2};
GN   Name=DCTN2-p50 {ECO:0000250|UniProtKB:Q7K2D2};
GN   Synonyms=Dmn {ECO:0000250|UniProtKB:Q7K2D2}; ORFNames=AGAP011690;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1] {ECO:0000312|EMBL:EAA00075.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000312|EMBL:EAA00075.3};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and
CC       plays a role in prometaphase chromosome alignment and spindle
CC       organization during mitosis. {ECO:0000250}.
CC   -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC       dynein. {ECO:0000250|UniProtKB:Q13561}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Membrane
CC       {ECO:0000250|UniProtKB:Q13561}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q13561}.
CC   -!- SIMILARITY: Belongs to the dynactin subunit 2 family. {ECO:0000255}.
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DR   EMBL; AAAB01008986; EAA00075.3; -; Genomic_DNA.
DR   RefSeq; XP_320820.3; XM_320820.4.
DR   AlphaFoldDB; Q7PZ25; -.
DR   SMR; Q7PZ25; -.
DR   STRING; 7165.AGAP011690-PA; -.
DR   PaxDb; Q7PZ25; -.
DR   GeneID; 1280947; -.
DR   KEGG; aga:AgaP_AGAP011690; -.
DR   CTD; 1280947; -.
DR   VEuPathDB; VectorBase:AGAP011690; -.
DR   eggNOG; KOG3958; Eukaryota.
DR   HOGENOM; CLU_049964_1_0_1; -.
DR   InParanoid; Q7PZ25; -.
DR   OMA; RGYDMRG; -.
DR   OrthoDB; 951183at2759; -.
DR   PhylomeDB; Q7PZ25; -.
DR   Proteomes; UP000007062; Chromosome 3L.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005869; C:dynactin complex; ISS:UniProtKB.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
DR   GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR   InterPro; IPR028133; Dynamitin.
DR   PANTHER; PTHR15346; PTHR15346; 1.
DR   Pfam; PF04912; Dynamitin; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule;
KW   Reference proteome.
FT   CHAIN           1..387
FT                   /note="Dynactin subunit 2"
FT                   /id="PRO_0000306374"
FT   COILED          99..125
FT                   /evidence="ECO:0000255"
FT   COILED          256..282
FT                   /evidence="ECO:0000255"
FT   COILED          355..387
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   387 AA;  42865 MW;  B017AC055374DF49 CRC64;
     MADPKFQYLP YIAHDQPDVY ETPDVNEAET SDYDEDEPVN DAIERLHIST KDSIGKFRGK
     YLTGEVDFSD GIGRKNRLGY DARSLDYELA GEGERETPLQ RCHRLKCEMN ELMEEIEASR
     ADTGRTAEEK ASHETVFGVV STAKKVLESL KLEQVIGSEV VAGGAGGGDA EAKKLIAQIE
     EYRKTGAVSS SDPKVVANEL VQSARVAQLE HRLHQLEVAV GAKPERISRL AGTTGTGNLI
     EAVQNISAKA ALLQPSQLDT IEQRLNNLLQ QMNSIQEKSN ATGQDPNREQ KILELYEIAK
     STEPIVQVLP DILNRMLTLE SLHKYATNFS KLFAELETTQ ASILNGVAAN KTLLTGVQEA
     FAQNLENVNK EVKKLEERMT KLQQMIK