DCTN2_CAEEL
ID DCTN2_CAEEL Reviewed; 331 AA.
AC Q09248;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Probable dynactin subunit 2;
GN Name=dnc-2; ORFNames=C28H8.12;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and
CC plays a role in prometaphase chromosome alignment and spindle
CC organization during mitosis. May play a role in synapse formation
CC during brain development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC dynein. {ECO:0000250}.
CC -!- INTERACTION:
CC Q09248; Q17353-2: par-3; NbExp=3; IntAct=EBI-316282, EBI-11467668;
CC Q09248; G5EF87: swsn-1; NbExp=2; IntAct=EBI-316282, EBI-311928;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the dynactin subunit 2 family. {ECO:0000305}.
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DR EMBL; FO080703; CCD65975.1; -; Genomic_DNA.
DR PIR; D88470; D88470.
DR RefSeq; NP_498286.1; NM_065885.5.
DR AlphaFoldDB; Q09248; -.
DR SMR; Q09248; -.
DR BioGRID; 41058; 49.
DR DIP; DIP-25501N; -.
DR IntAct; Q09248; 20.
DR STRING; 6239.C28H8.12; -.
DR EPD; Q09248; -.
DR PaxDb; Q09248; -.
DR PeptideAtlas; Q09248; -.
DR EnsemblMetazoa; C28H8.12.1; C28H8.12.1; WBGene00001018.
DR EnsemblMetazoa; C28H8.12.2; C28H8.12.2; WBGene00001018.
DR GeneID; 175837; -.
DR KEGG; cel:CELE_C28H8.12; -.
DR UCSC; C28H8.12; c. elegans.
DR CTD; 175837; -.
DR WormBase; C28H8.12; CE01823; WBGene00001018; dnc-2.
DR eggNOG; KOG3958; Eukaryota.
DR GeneTree; ENSGT00390000003427; -.
DR HOGENOM; CLU_049964_0_0_1; -.
DR InParanoid; Q09248; -.
DR OMA; ETRANND; -.
DR OrthoDB; 951183at2759; -.
DR PhylomeDB; Q09248; -.
DR Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR Reactome; R-CEL-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR SignaLink; Q09248; -.
DR PRO; PR:Q09248; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00001018; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005813; C:centrosome; IDA:WormBase.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005869; C:dynactin complex; IDA:WormBase.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IDA:UniProtKB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:WormBase.
DR GO; GO:0000242; C:pericentriolar material; IDA:WormBase.
DR GO; GO:0005876; C:spindle microtubule; IDA:WormBase.
DR GO; GO:0035047; P:centrosomal and pronuclear rotation; IMP:WormBase.
DR GO; GO:0007059; P:chromosome segregation; IMP:WormBase.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IMP:WormBase.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR GO; GO:0007097; P:nuclear migration; IMP:WormBase.
DR GO; GO:0035046; P:pronuclear migration; IMP:WormBase.
DR InterPro; IPR028133; Dynamitin.
DR PANTHER; PTHR15346; PTHR15346; 2.
DR Pfam; PF04912; Dynamitin; 2.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule;
KW Reference proteome.
FT CHAIN 1..331
FT /note="Probable dynactin subunit 2"
FT /id="PRO_0000065200"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 90..123
FT /evidence="ECO:0000255"
FT COILED 209..249
FT /evidence="ECO:0000255"
FT COILED 280..331
FT /evidence="ECO:0000255"
SQ SEQUENCE 331 AA; 37155 MW; 29034768AC7AB23E CRC64;
MSSIGKEDIY ESDGAASQVQ KSEPENDNPT HPDIELISVD VDEALKKYKN RVLNLTSSDF
SDSIAKKRRH AFGNNQYVLE VTGAGFSGTE TAAEKLNRIL YEVADLNEQI RADENLKTDL
LNAEVLENLE KEVKTLQVAQ SNGKTARVEH DVELPNVRTD SKVATLENRL RRIEQVIGSS
VIPSAPVLDT IEDLKLRCET LNHSYVSGLE QRLNMMLTKL EKIDETRANN DIDENLDKKV
DEILELMQKW DVACSSLPSN VNKVKALNRL HEQVQHFAGG LSHLKTIREK LEKEVAQGRE
AIIEYESQGK QEIGSVVEKL KLLEAKVADL K