ID   DCTN2_CHICK             Reviewed;         402 AA.
AC   Q9PTG6;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Dynactin subunit 2;
DE   AltName: Full=p50 dynamitin;
GN   Name=DCTN2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Schroer T.A., Gill S.R., Hasbani J., Crego C.;
RT   "Chicken p50-dynamitin, a subunit of dynactin complex.";
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and
CC       plays a role in prometaphase chromosome alignment and spindle
CC       organization during mitosis. Involved in anchoring microtubules to
CC       centrosomes. May play a role in synapse formation during brain
CC       development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC       dynein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynactin subunit 2 family. {ECO:0000305}.
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DR   EMBL; AF200744; AAF13996.1; -; mRNA.
DR   AlphaFoldDB; Q9PTG6; -.
DR   BioGRID; 675866; 1.
DR   IntAct; Q9PTG6; 1.
DR   STRING; 9031.ENSGALP00000043356; -.
DR   VEuPathDB; HostDB:geneid_395587; -.
DR   InParanoid; Q9PTG6; -.
DR   OrthoDB; 951183at2759; -.
DR   PhylomeDB; Q9PTG6; -.
DR   PRO; PR:Q9PTG6; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005869; C:dynactin complex; IBA:GO_Central.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   InterPro; IPR028133; Dynamitin.
DR   PANTHER; PTHR15346; PTHR15346; 1.
DR   Pfam; PF04912; Dynamitin; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule;
KW   Reference proteome.
FT   CHAIN           1..402
FT                   /note="Dynactin subunit 2"
FT                   /id="PRO_0000288767"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          101..132
FT                   /evidence="ECO:0000255"
FT   COILED          357..402
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   402 AA;  45126 MW;  F229C467C630DCB9 CRC64;
     MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFEAELEEL TSTSVEHLII NPNAAFEKFK
     DKRLGTDGVD FSDRISKSRT TGYESGEYEI LGEGLGAKET PQQRYQRLQH EVQELIRDVE
     QIQSAVKESA AEEELTPMAL ARQLEGLKQQ LVSCHLQKLL GPTAAIDFAD PEGALAKRLQ
     QQLEVPSVKK AAPAKSPPKA PGPTTDALTF ELFWRRPEQD QFSQTAKIAE LEKRLAQLEA
     MVRCEPDSQN PLLVGAEGTS LVETVQILQA KVNILDAAVL DQVEARLQRR PGSKVNEIAK
     HKAIVQDADT QSKIHQVVYE MMQRWDHMAS SLPDVVQRLL TLRDLHEQAS RFVQVLVHLD
     TTQQEVDVVQ RLLAEVQKTM KENLAVVEDN FAEVEARIKR LQ