ID   DCTN2_DANRE             Reviewed;         405 AA.
AC   Q7T3H1; Q07DR0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Dynactin subunit 2;
GN   Name=dctn2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tsujikawa M., Malicki J.;
RT   "Nuclear positioning in vertebrate photoreceptor cells.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and
CC       plays a role in prometaphase chromosome alignment and spindle
CC       organization during mitosis. Involved in anchoring microtubules to
CC       centrosomes. May play a role in synapse formation during brain
CC       development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC       dynein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynactin subunit 2 family. {ECO:0000305}.
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DR   EMBL; DQ141218; ABA29743.1; -; mRNA.
DR   EMBL; BC053120; AAH53120.1; -; mRNA.
DR   RefSeq; NP_957460.1; NM_201166.1.
DR   AlphaFoldDB; Q7T3H1; -.
DR   SMR; Q7T3H1; -.
DR   STRING; 7955.ENSDARP00000093918; -.
DR   PaxDb; Q7T3H1; -.
DR   GeneID; 394141; -.
DR   KEGG; dre:394141; -.
DR   CTD; 10540; -.
DR   ZFIN; ZDB-GENE-040426-1279; dctn2.
DR   eggNOG; KOG3958; Eukaryota.
DR   InParanoid; Q7T3H1; -.
DR   OrthoDB; 951183at2759; -.
DR   PhylomeDB; Q7T3H1; -.
DR   Reactome; R-DRE-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-DRE-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR   Reactome; R-DRE-380259; Loss of Nlp from mitotic centrosomes.
DR   Reactome; R-DRE-380270; Recruitment of mitotic centrosome proteins and complexes.
DR   Reactome; R-DRE-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR   Reactome; R-DRE-380320; Recruitment of NuMA to mitotic centrosomes.
DR   Reactome; R-DRE-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-DRE-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-DRE-8854518; AURKA Activation by TPX2.
DR   PRO; PR:Q7T3H1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005869; C:dynactin complex; IBA:GO_Central.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR   GO; GO:0060117; P:auditory receptor cell development; IMP:ZFIN.
DR   GO; GO:0035088; P:establishment or maintenance of apical/basal cell polarity; IMP:ZFIN.
DR   GO; GO:0001754; P:eye photoreceptor cell differentiation; IMP:ZFIN.
DR   GO; GO:0010001; P:glial cell differentiation; IMP:ZFIN.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   GO; GO:0007097; P:nuclear migration; IMP:ZFIN.
DR   GO; GO:0030719; P:P granule organization; IMP:ZFIN.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; IMP:ZFIN.
DR   InterPro; IPR028133; Dynamitin.
DR   PANTHER; PTHR15346; PTHR15346; 1.
DR   Pfam; PF04912; Dynamitin; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule;
KW   Reference proteome.
FT   CHAIN           1..405
FT                   /note="Dynactin subunit 2"
FT                   /id="PRO_0000288768"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          102..125
FT                   /evidence="ECO:0000255"
FT   COILED          379..405
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   405 AA;  44625 MW;  CA00047342500953 CRC64;
     MADPKYANLP GIASNEPDVY ETSDLPEDDQ AQFESELEEL CSDSVERIVV NPNAAYDKFK
     DKHVSAKSLD FSDRISKNRR VGYESGDYEL LAEGCGVKET PQQKYQRLVN EIHELCQDVE
     KIQTSTKESG AEERLTPVAL AQQAAQLKQQ LVSAHLDSLL GPDAHINLTD PDGALAKRLL
     TQLEVARGVR SGAGADGKTA APKGPDGVIL YELHSRPEQE KFTESAKVAE LERRLAELET
     AVGSGSDKRG PLSSGVQGSS LTETLELLQA RVSALDAATL DQVEARLQSV LGKMNEIAKH
     KATMEDAETQ SKVSQLYDVV QKWDAMATSL PQVVRRLTAV RELHEQAMQF GQLLTHLDTT
     QQMINNSLKD NSTLLTQVQQ TMKENLLAVE ENFSALDQRM KKLNK