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DCTN2_DROPS
ID   DCTN2_DROPS             Reviewed;         380 AA.
AC   Q28Y46;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Dynactin subunit 2;
DE   AltName: Full=Dynactin 2 p50 subunit {ECO:0000250|UniProtKB:Q7K2D2};
GN   Name=DCTN2-p50 {ECO:0000250|UniProtKB:Q7K2D2};
GN   Synonyms=Dmn {ECO:0000250|UniProtKB:Q7K2D2}; ORFNames=GA20943;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and
CC       plays a role in prometaphase chromosome alignment and spindle
CC       organization during mitosis. May play a role in synapse formation
CC       during brain development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC       dynein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynactin subunit 2 family. {ECO:0000305}.
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DR   EMBL; CM000071; EAL26119.1; -; Genomic_DNA.
DR   RefSeq; XP_001361541.1; XM_001361504.3.
DR   AlphaFoldDB; Q28Y46; -.
DR   SMR; Q28Y46; -.
DR   STRING; 7237.FBpp0278394; -.
DR   EnsemblMetazoa; FBtr0279956; FBpp0278394; FBgn0080932.
DR   GeneID; 4805079; -.
DR   KEGG; dpo:Dpse_GA20943; -.
DR   eggNOG; KOG3958; Eukaryota.
DR   HOGENOM; CLU_049964_1_0_1; -.
DR   InParanoid; Q28Y46; -.
DR   OMA; RGYDMRG; -.
DR   PhylomeDB; Q28Y46; -.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0080932; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
DR   GO; GO:0005869; C:dynactin complex; ISS:UniProtKB.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR   GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR   GO; GO:0061883; P:clathrin-dependent endocytosis involved in vitellogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
DR   GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR   GO; GO:0051028; P:mRNA transport; IEA:EnsemblMetazoa.
DR   GO; GO:0016325; P:oocyte microtubule cytoskeleton organization; IEA:EnsemblMetazoa.
DR   GO; GO:0007602; P:phototransduction; IEA:EnsemblMetazoa.
DR   GO; GO:0045451; P:pole plasm oskar mRNA localization; IEA:EnsemblMetazoa.
DR   GO; GO:2001019; P:positive regulation of retrograde axon cargo transport; IEA:EnsemblMetazoa.
DR   GO; GO:0008090; P:retrograde axonal transport; IEA:EnsemblMetazoa.
DR   InterPro; IPR028133; Dynamitin.
DR   PANTHER; PTHR15346; PTHR15346; 1.
DR   Pfam; PF04912; Dynamitin; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule;
KW   Reference proteome.
FT   CHAIN           1..380
FT                   /note="Dynactin subunit 2"
FT                   /id="PRO_0000288773"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          100..135
FT                   /evidence="ECO:0000255"
FT   COILED          353..377
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        20..39
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   380 AA;  42136 MW;  386BCF12F74EAAFC CRC64;
     MADPKFQNLP GIAYDQPDVY ETPDDPETDT SDYYEEEPEN EAIERMHISA SAAHKRFSGA
     TLEGSVDFTD RIGRRPGRGY DMRGAGEYEL VGQGEKETPV QKCQRLQIEM NELLNEVAAL
     QVDRKIADEE KQSYDAVATV ISTAKKVLDT LKLEQVLGKE QVPNSKQVKA LISQVEEFKQ
     SGVLTAIPTP GTDLASTARV ASLEQRLYQL EKTVGAQPEK LSRLNAATNT TNVLEAVRQL
     STKAALLQPD KLDTIEQRLT TLAGKMDSIA EKSSGSSQDA KRDQKISELY DIAKRTEPVV
     EILPHVIERM QALESLHKYA NNFAKIIAEI EHKQGTITTS LVNNKELLHS VQETFAQNLE
     TITNKVAKVE QRVTAISTAK
 
 
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