ID   DCTN2_XENTR             Reviewed;         405 AA.
AC   Q5FW42;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Dynactin subunit 2;
GN   Name=dctn2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and
CC       plays a role in prometaphase chromosome alignment and spindle
CC       organization during mitosis. Involved in anchoring microtubules to
CC       centrosomes. May play a role in synapse formation during brain
CC       development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC       dynein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynactin subunit 2 family. {ECO:0000305}.
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DR   EMBL; BC089637; AAH89637.1; -; mRNA.
DR   RefSeq; NP_001015706.1; NM_001015706.1.
DR   AlphaFoldDB; Q5FW42; -.
DR   PaxDb; Q5FW42; -.
DR   DNASU; 548423; -.
DR   Ensembl; ENSXETT00000013692; ENSXETP00000013692; ENSXETG00000006234.
DR   GeneID; 548423; -.
DR   KEGG; xtr:548423; -.
DR   CTD; 10540; -.
DR   Xenbase; XB-GENE-1000632; dctn2.
DR   eggNOG; KOG3958; Eukaryota.
DR   HOGENOM; CLU_049964_1_0_1; -.
DR   InParanoid; Q5FW42; -.
DR   OrthoDB; 951183at2759; -.
DR   Reactome; R-XTR-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-XTR-380259; Loss of Nlp from mitotic centrosomes.
DR   Reactome; R-XTR-380270; Recruitment of mitotic centrosome proteins and complexes.
DR   Reactome; R-XTR-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR   Reactome; R-XTR-380320; Recruitment of NuMA to mitotic centrosomes.
DR   Reactome; R-XTR-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-XTR-8854518; AURKA Activation by TPX2.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000006234; Expressed in testis and 15 other tissues.
DR   ExpressionAtlas; Q5FW42; baseline.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005869; C:dynactin complex; IBA:GO_Central.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   InterPro; IPR028133; Dynamitin.
DR   PANTHER; PTHR15346; PTHR15346; 1.
DR   Pfam; PF04912; Dynamitin; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule;
KW   Reference proteome.
FT   CHAIN           1..405
FT                   /note="Dynactin subunit 2"
FT                   /id="PRO_0000288771"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          101..134
FT                   /evidence="ECO:0000255"
FT   COILED          383..403
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   405 AA;  45005 MW;  2D5201E50CD4F008 CRC64;
     MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFDAELEEL TSTSVEHIIV NPNAAYDKFK
     DKKVGTRGLD FSDRITKSKR TGYESGEYEI LGEGIGIKET PQQKYQRLLH EIQELTQEVE
     KAQSTVKESA AEEKLTPVAL AKQVAALKQQ LVSTHLEKLL GPDAAINLTD PDGALAKRLL
     TQLDVAKTRK NPEGKSPAKG PGPDNENFVT YELHCRPEQN KFSQAAKMAE LEKRLGELEA
     AVRNDQDTQN PLTVGLQGSC LMDTVEILQA KVNLLDVASL DQVEARLQSV LGKMNEIAKH
     KAAIEDADTE SKVHQLYETV QKWDSMSSTL PQVVQRLLML KQLHEQAMQF GQLLAHLDTT
     QQMISNSLKD NTNALAMVQK AMKENLATVE DNFTSIDARI KKLSK