ID   DCTN3_BOVIN             Reviewed;         186 AA.
AC   Q0P5A1;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Dynactin subunit 3;
GN   Name=DCTN3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Together with dynein may be involved in spindle assembly and
CC       cytokinesis. {ECO:0000250}.
CC   -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC       dynein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       microtubule organizing center, centrosome {ECO:0000250}. Chromosome,
CC       centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}.
CC       Note=Localizes to punctate cytoplasmic structures and to the centrosome
CC       during interphase, and to kinetochores and to spindle poles throughout
CC       mitosis. Colocalizes with dynein to the cleavage furrow and to midbody
CC       of dividing cells (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynactin subunit 3 family. {ECO:0000305}.
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DR   EMBL; BC120309; AAI20310.1; -; mRNA.
DR   RefSeq; NP_001069128.1; NM_001075660.1.
DR   AlphaFoldDB; Q0P5A1; -.
DR   SMR; Q0P5A1; -.
DR   CORUM; Q0P5A1; -.
DR   STRING; 9913.ENSBTAP00000025136; -.
DR   PaxDb; Q0P5A1; -.
DR   PRIDE; Q0P5A1; -.
DR   Ensembl; ENSBTAT00000025136; ENSBTAP00000025136; ENSBTAG00000018883.
DR   GeneID; 514327; -.
DR   KEGG; bta:514327; -.
DR   CTD; 11258; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018883; -.
DR   VGNC; VGNC:27930; DCTN3.
DR   eggNOG; ENOG502RYZ0; Eukaryota.
DR   GeneTree; ENSGT00390000016210; -.
DR   HOGENOM; CLU_121487_1_0_1; -.
DR   InParanoid; Q0P5A1; -.
DR   OMA; EYNKMTI; -.
DR   OrthoDB; 1444664at2759; -.
DR   TreeFam; TF105248; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000018883; Expressed in retina and 104 other tissues.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005869; C:dynactin complex; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0061640; P:cytoskeleton-dependent cytokinesis; IBA:GO_Central.
DR   GO; GO:0007017; P:microtubule-based process; IEA:Ensembl.
DR   InterPro; IPR009991; DCTN3.
DR   PANTHER; PTHR28360; PTHR28360; 1.
DR   Pfam; PF07426; Dynactin_p22; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell cycle; Cell division; Centromere; Chromosome;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Kinetochore; Mitosis;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O75935"
FT   CHAIN           2..186
FT                   /note="Dynactin subunit 3"
FT                   /id="PRO_0000282603"
FT   COILED          135..157
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:O75935"
SQ   SEQUENCE   186 AA;  21192 MW;  1B6E328169528380 CRC64;
     MAAVTDVQRL QARVEELERW VYGPGGSRGS RKVADGLVKV QVALGNIASK RERVKVLYKK
     IEDLIKYLDP EYIDRIALPD ASKLQFILAE EQFILSQVAL LEQVEALVPM LDSTHIKAVP
     EHAARLQRLA QIHIQQQDQC VEITEESKAL LEEYNKTTML LSKQFVQWDE LLCQLEAAKQ
     VKPVEE