DCTN5_MOUSE
ID DCTN5_MOUSE Reviewed; 182 AA.
AC Q9QZB9; Q3U9A4; Q8BPE5; Q91XC6; Q99J17;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Dynactin subunit 5;
DE AltName: Full=Dynactin subunit p25;
GN Name=Dctn5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBUNIT.
RX PubMed=10525537; DOI=10.1083/jcb.147.2.307;
RA Eckley D.M., Gill S.R., Melkonian K.A., Bingham J.B., Goodson H.V.,
RA Heuser J.E., Schroer T.A.;
RT "Analysis of dynactin subcomplexes reveals a novel actin-related protein
RT associated with the Arp1 minifilament pointed end.";
RL J. Cell Biol. 147:307-320(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Amnion, Bone marrow, Embryo, Eye, Testis, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Member of the pointed-end complex of the dynactin shoulder
CC complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10.
CC Within the complex DCTN6 forms a heterodimer with DCTN5.
CC {ECO:0000269|PubMed:10525537}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC Chromosome, centromere, kinetochore {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the dynactin subunits 5/6 family. Dynactin
CC subunit 5 subfamily. {ECO:0000305}.
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DR EMBL; AF190795; AAF05615.1; -; mRNA.
DR EMBL; AK010238; BAB26789.1; -; mRNA.
DR EMBL; AK051957; BAC34820.1; -; mRNA.
DR EMBL; AK076100; BAC36183.1; -; mRNA.
DR EMBL; AK076738; BAC36460.1; -; mRNA.
DR EMBL; AK151193; BAE30190.1; -; mRNA.
DR EMBL; AK151876; BAE30763.1; -; mRNA.
DR EMBL; AK168983; BAE40783.1; -; mRNA.
DR EMBL; BC010834; AAH10834.1; -; mRNA.
DR EMBL; BC005671; AAH05671.1; -; mRNA.
DR CCDS; CCDS21811.1; -.
DR RefSeq; NP_067621.3; NM_021608.3.
DR AlphaFoldDB; Q9QZB9; -.
DR SMR; Q9QZB9; -.
DR BioGRID; 208544; 19.
DR IntAct; Q9QZB9; 19.
DR MINT; Q9QZB9; -.
DR STRING; 10090.ENSMUSP00000033156; -.
DR iPTMnet; Q9QZB9; -.
DR PhosphoSitePlus; Q9QZB9; -.
DR EPD; Q9QZB9; -.
DR MaxQB; Q9QZB9; -.
DR PaxDb; Q9QZB9; -.
DR PeptideAtlas; Q9QZB9; -.
DR PRIDE; Q9QZB9; -.
DR ProteomicsDB; 279841; -.
DR Antibodypedia; 43088; 101 antibodies from 18 providers.
DR DNASU; 59288; -.
DR Ensembl; ENSMUST00000033156; ENSMUSP00000033156; ENSMUSG00000030868.
DR GeneID; 59288; -.
DR KEGG; mmu:59288; -.
DR UCSC; uc009jon.2; mouse.
DR CTD; 84516; -.
DR MGI; MGI:1891689; Dctn5.
DR VEuPathDB; HostDB:ENSMUSG00000030868; -.
DR eggNOG; KOG3121; Eukaryota.
DR GeneTree; ENSGT00390000015360; -.
DR HOGENOM; CLU_088622_2_0_1; -.
DR InParanoid; Q9QZB9; -.
DR OMA; IAIGRYC; -.
DR OrthoDB; 1270774at2759; -.
DR PhylomeDB; Q9QZB9; -.
DR TreeFam; TF314194; -.
DR Reactome; R-MMU-2132295; MHC class II antigen presentation.
DR Reactome; R-MMU-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR Reactome; R-MMU-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR BioGRID-ORCS; 59288; 27 hits in 73 CRISPR screens.
DR ChiTaRS; Dctn5; mouse.
DR PRO; PR:Q9QZB9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9QZB9; protein.
DR Bgee; ENSMUSG00000030868; Expressed in floor plate of midbrain and 260 other tissues.
DR ExpressionAtlas; Q9QZB9; baseline and differential.
DR Genevisible; Q9QZB9; MM.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005869; C:dynactin complex; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0035904; P:aorta development; IMP:MGI.
DR GO; GO:0060976; P:coronary vasculature development; IMP:MGI.
DR GO; GO:0003281; P:ventricular septum development; IMP:MGI.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR Pfam; PF00132; Hexapep; 1.
DR SUPFAM; SSF51161; SSF51161; 1.
PE 1: Evidence at protein level;
KW Acetylation; Centromere; Chromosome; Cytoplasm; Cytoskeleton; Kinetochore;
KW Reference proteome.
FT CHAIN 1..182
FT /note="Dynactin subunit 5"
FT /id="PRO_0000079828"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9BTE1"
FT CONFLICT 11
FT /note="S -> L (in Ref. 3; AAH10834)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="E -> G (in Ref. 2; BAC36183)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 182 AA; 20141 MW; 476DAB4B7805D496 CRC64;
MELGELLYNK SEYIETASGN KVSRQSVLCG SQNIVLNGKT IIMNDCIIRG DLANVRVGRH
CVVKSRSVIR PPFKKFSKGV AFFPLHIGDH VFIEEDCVVN AAQIGSYVHV GKNCVIGRRC
VLKDCCKILD NTVLPPETVV PPFTVFSGCP GLFSGELPEC TQELMIDVTK SYYQKFLPLT
QV
