ID   DCTN6_BOVIN             Reviewed;         190 AA.
AC   Q148G7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Dynactin subunit 6;
GN   Name=DCTN6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Member of the pointed-end complex of the dynactin shoulder
CC       complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10.
CC       Within the complex DCTN6 forms a heterodimer with DCTN5. Interacts with
CC       PLK1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC       Chromosome, centromere, kinetochore {ECO:0000250}.
CC   -!- PTM: Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase
CC       creates a binding site for PLK1 that facilitates its recruitment to
CC       kinetochores. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynactin subunits 5/6 family. Dynactin
CC       subunit 6 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC118351; AAI18352.1; -; mRNA.
DR   RefSeq; NP_001069106.1; NM_001075638.2.
DR   AlphaFoldDB; Q148G7; -.
DR   SMR; Q148G7; -.
DR   BioGRID; 170378; 1.
DR   CORUM; Q148G7; -.
DR   IntAct; Q148G7; 2.
DR   STRING; 9913.ENSBTAP00000000989; -.
DR   PaxDb; Q148G7; -.
DR   PRIDE; Q148G7; -.
DR   Ensembl; ENSBTAT00000000989; ENSBTAP00000000989; ENSBTAG00000000744.
DR   GeneID; 513751; -.
DR   KEGG; bta:513751; -.
DR   CTD; 10671; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000744; -.
DR   VGNC; VGNC:27933; DCTN6.
DR   eggNOG; KOG4042; Eukaryota.
DR   GeneTree; ENSGT00390000017890; -.
DR   HOGENOM; CLU_085418_1_0_1; -.
DR   InParanoid; Q148G7; -.
DR   OMA; PDYTVVY; -.
DR   OrthoDB; 1278795at2759; -.
DR   TreeFam; TF352888; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000000744; Expressed in occipital lobe and 108 other tissues.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005869; C:dynactin complex; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0070840; F:dynein complex binding; IBA:GO_Central.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   InterPro; IPR027777; DCTN6.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   PANTHER; PTHR13072; PTHR13072; 1.
DR   Pfam; PF00132; Hexapep; 1.
DR   SUPFAM; SSF51161; SSF51161; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Cytoplasm; Cytoskeleton; Kinetochore;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..190
FT                   /note="Dynactin subunit 6"
FT                   /id="PRO_0000327742"
FT   MOD_RES         186
FT                   /note="Phosphothreonine; by CDK1"
FT                   /evidence="ECO:0000250|UniProtKB:O00399"
SQ   SEQUENCE   190 AA;  20675 MW;  67BEF26EEA255D9D CRC64;
     MAEKTQKSVK IAPGAVVCVE SEIRGDVTIG PRTVIHPKAR IIAEAGPIVI GEGNLIEEQA
     LIINAHPDNI TPDAEDPEPK PMIIGTNNVF EVGCYCQAMK IGDNNVIESK AYVGRNVILT
     SGCIIGACCN LNTFEVIPEN TVIYGGDCLR RVQTERPQPQ TLQLDFLMKI LPNYHHLKKT
     MKGSSTPVKN