ID   ACT_GIAIN               Reviewed;         375 AA.
AC   P51775;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Actin;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8587128; DOI=10.1007/bf00173163;
RA   Drouin G., Moniz de Sa M., Zuker M.;
RT   "The Giardia lamblia actin gene and the phylogeny of eukaryotes.";
RL   J. Mol. Evol. 41:841-849(1995).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L29032; AAA99305.1; -; Genomic_DNA.
DR   RefSeq; XP_001704653.1; XM_001704601.1.
DR   AlphaFoldDB; P51775; -.
DR   SMR; P51775; -.
DR   GeneID; 5697520; -.
DR   KEGG; gla:GL50803_0040817; -.
DR   VEuPathDB; GiardiaDB:DHA2_40817; -.
DR   VEuPathDB; GiardiaDB:GL50581_16; -.
DR   VEuPathDB; GiardiaDB:GL50803_0040817; -.
DR   eggNOG; KOG0676; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   CHAIN           1..375
FT                   /note="Actin"
FT                   /id="PRO_0000088944"
SQ   SEQUENCE   375 AA;  41586 MW;  D33CB8F849022D1B CRC64;
     MTDDNPAIVI DNGSGMCKAG FAGDDAPRAV FPTVVGRPKR ETVLVGSTHK EEYIGDEALA
     KRGVLKLSYP IEHGQIKDWD MMEKVWHHCY FNELRAQPSD HAVLLTEAPK NPKANREKIC
     QIMFETFAVP AFYVQVQAVL ALYSSGRTTG IVIDTGDGVT HTVPVYEGYS LPHAVLRSEI
     AGKELTDFCQ INLQENGASF TTSAEFEIVR DIKEKLCFVA LDYESVLAAS MESANYTKTY
     ELPDGVVITV NQARFKTPEL LFRPELNNSD MDGIHQLCYK TIQKCDIDIR SELYSNVVLS
     GGSSMFAGLP ERLEKELLDL IPAGKRVRIS SPEDRKYSAW VGGSVLGSLA TFESMWVSSQ
     EYQENGASIA NRKCM