ID   DCTN6_PONAB             Reviewed;         190 AA.
AC   Q5R7D8;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Dynactin subunit 6;
DE   AltName: Full=Dynactin subunit p27;
GN   Name=DCTN6;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Member of the pointed-end complex of the dynactin shoulder
CC       complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10.
CC       Within the complex DCTN6 forms a heterodimer with DCTN5. Interacts with
CC       PLK1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC       Chromosome, centromere, kinetochore {ECO:0000250}.
CC   -!- PTM: Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase
CC       creates a binding site for PLK1 that facilitates its recruitment to
CC       kinetochores. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynactin subunits 5/6 family. Dynactin
CC       subunit 6 subfamily. {ECO:0000305}.
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DR   EMBL; CR860180; CAH92322.1; -; mRNA.
DR   RefSeq; NP_001127539.1; NM_001134067.2.
DR   AlphaFoldDB; Q5R7D8; -.
DR   SMR; Q5R7D8; -.
DR   STRING; 9601.ENSPPYP00000020722; -.
DR   GeneID; 100174616; -.
DR   KEGG; pon:100174616; -.
DR   CTD; 10671; -.
DR   eggNOG; KOG4042; Eukaryota.
DR   InParanoid; Q5R7D8; -.
DR   OrthoDB; 1278795at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005869; C:dynactin complex; IEA:InterPro.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   InterPro; IPR027777; DCTN6.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   PANTHER; PTHR13072; PTHR13072; 1.
DR   Pfam; PF00132; Hexapep; 1.
DR   SUPFAM; SSF51161; SSF51161; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Cytoplasm; Cytoskeleton; Kinetochore;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..190
FT                   /note="Dynactin subunit 6"
FT                   /id="PRO_0000079832"
FT   MOD_RES         186
FT                   /note="Phosphothreonine; by CDK1"
FT                   /evidence="ECO:0000250|UniProtKB:O00399"
SQ   SEQUENCE   190 AA;  20713 MW;  77ABB8C0029C77B7 CRC64;
     MAEKTQKSVK IAPGAVVCVE SEIRGDVTIG PRTVIHPKAR IIAEAGPIVI GEGNLIEEQA
     LIINAYPDNI TPDTEDPEPK PMIIGTNNVF EVGCYSQAMK MGDNNVIESK AYVGRNVILT
     SGCIIGACCN LNTFEVIPEN TVIYGADCLR RVQTERPQPQ TLQLDLLMKI LPNYHHLKKT
     MKGSSTPVKN