ID   DCTP_VIBCH              Reviewed;         332 AA.
AC   Q9KQR9;
DT   20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=C4-dicarboxylate-binding periplasmic protein DctP {ECO:0000305};
DE   Flags: Precursor;
GN   Name=dctP {ECO:0000303|PubMed:22556361};
GN   OrderedLocusNames=VC_1929 {ECO:0000312|EMBL:AAF95077.1};
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [2]
RP   PRELIMINARY FUNCTION.
RX   PubMed=21873407; DOI=10.1099/mic.0.050245-0;
RA   Sharma S.K., Moe T.S., Srivastava R., Chandra D., Srivastava B.S.;
RT   "Functional characterization of VC1929 of Vibrio cholerae El Tor: role in
RT   mannose-sensitive haemagglutination, virulence and utilization of sialic
RT   acid.";
RL   Microbiology 157:3180-3186(2011).
RN   [3]
RP   DISCUSSION OF FUNCTION.
RX   PubMed=21980116; DOI=10.1099/mic.0.054692-0;
RA   Thomas G.H., Boyd E.F.;
RT   "On sialic acid transport and utilization by Vibrio cholerae.";
RL   Microbiology 157:3253-3254(2011).
RN   [4]
RP   PROBABLE FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22556361; DOI=10.1099/mic.0.059659-0;
RA   Chowdhury N., Norris J., McAlister E., Lau S.Y., Thomas G.H., Boyd E.F.;
RT   "The VC1777-VC1779 proteins are members of a sialic acid-specific subfamily
RT   of TRAP transporters (SiaPQM) and constitute the sole route of sialic acid
RT   uptake in the human pathogen Vibrio cholerae.";
RL   Microbiology 158:2158-2167(2012).
CC   -!- FUNCTION: Part of the tripartite ATP-independent periplasmic (TRAP)
CC       transport system DctPQM involved in C4-dicarboxylates uptake.
CC       {ECO:0000305|PubMed:22556361}.
CC   -!- SUBUNIT: The complex comprises the extracytoplasmic solute receptor
CC       protein DctP, and the two transmembrane proteins DctQ and DctM.
CC       {ECO:0000250|UniProtKB:P37735}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250|UniProtKB:P37735}.
CC   -!- DISRUPTION PHENOTYPE: Disruption decreases growth on C4-dicarboxylates
CC       succinate, fumarate and L-malate as sole carbon sources, but does not
CC       affect growth on sialic acid. {ECO:0000269|PubMed:22556361}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 7 family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Was proposed to function as a mannose-sensitive hemagglutinin
CC       and a virulence factor, and to be involved in the utilization of sialic
CC       acid (PubMed:21873407). However, it was later shown to be probably part
CC       of a C4-dicarboxylate TRAP transporter (PubMed:21980116,
CC       PubMed:22556361). {ECO:0000305|PubMed:21873407,
CC       ECO:0000305|PubMed:21980116, ECO:0000305|PubMed:22556361}.
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DR   EMBL; AE003852; AAF95077.1; -; Genomic_DNA.
DR   PIR; F82140; F82140.
DR   RefSeq; NP_231563.1; NC_002505.1.
DR   RefSeq; WP_000476112.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KQR9; -.
DR   SMR; Q9KQR9; -.
DR   STRING; 243277.VC_1929; -.
DR   PRIDE; Q9KQR9; -.
DR   DNASU; 2613558; -.
DR   EnsemblBacteria; AAF95077; AAF95077; VC_1929.
DR   GeneID; 57740560; -.
DR   KEGG; vch:VC_1929; -.
DR   PATRIC; fig|243277.26.peg.1846; -.
DR   eggNOG; COG1638; Bacteria.
DR   HOGENOM; CLU_036176_1_3_6; -.
DR   OMA; AFWHNGM; -.
DR   BioCyc; VCHO:VC1929-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0015740; P:C4-dicarboxylate transport; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 3.40.190.170; -; 1.
DR   InterPro; IPR018389; DctP_fam.
DR   InterPro; IPR004682; TRAP_DctP.
DR   InterPro; IPR038404; TRAP_DctP_sf.
DR   PANTHER; PTHR33376; PTHR33376; 1.
DR   Pfam; PF03480; DctP; 1.
DR   PIRSF; PIRSF006470; DctB; 1.
DR   TIGRFAMs; TIGR00787; dctP; 1.
PE   3: Inferred from homology;
KW   Periplasm; Reference proteome; Signal; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..332
FT                   /note="C4-dicarboxylate-binding periplasmic protein DctP"
FT                   /id="PRO_5004328486"
SQ   SEQUENCE   332 AA;  37095 MW;  D6DAD0D34130931F CRC64;
     MFKPLTLIAA SILAVTSFNA AANCDPGEIV IKFSHVTNTD KHPKGIAASL LEKRVNEEMN
     GKACMQVFPN STLYDDDKVL EALLNGDVQL AAPSLSKFEK FTKKYRIFDL PFLFEDVDAV
     DRFQSSAKGE ELKNAMTRRG VKGLEFWHNG MKQISANKPI LVPADAKGLK FRVQASDVLV
     AQFEQIGANP QKMSFAETYG GLQTKVIDGQ ENTWSNIYGQ KYFEVQDGTT ETNHGILDYL
     VVTSSKWWDG LPADVRDQFA KILNEVTIER NAESNKVEEL NKQYIIEAGG VVRTLTPEQR
     QQWVDALKPV WQKFEKDIGA DLIEAALAAN QK