DCTR_BACSU
ID DCTR_BACSU Reviewed; 226 AA.
AC P96602; P94503;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Probable C4-dicarboxylate response regulator DctR;
GN Name=dctR; Synonyms=ydbG; OrderedLocusNames=BSU04460;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT subtilis genome.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 14-101.
RC STRAIN=SB202;
RX PubMed=9168601; DOI=10.1099/00221287-143-5-1513;
RA Morel-Deville F., Ehrlich S.D., Morel P.;
RT "Identification by PCR of genes encoding multiple response regulators.";
RL Microbiology 143:1513-1520(1997).
RN [4]
RP FUNCTION, AND GENE NAME.
RC STRAIN=168;
RX PubMed=10708364; DOI=10.1099/00221287-146-2-263;
RA Asai K., Baik S.-H., Kasahara Y., Moriya S., Ogasawara N.;
RT "Regulation of the transport system for C4-dicarboxylic acids in Bacillus
RT subtilis.";
RL Microbiology 146:263-271(2000).
RN [5]
RP FUNCTION.
RX PubMed=11717295; DOI=10.1128/jb.183.24.7365-7370.2001;
RA Kobayashi K., Ogura M., Yamaguchi H., Yoshida K., Ogasawara N., Tanaka T.,
RA Fujita Y.;
RT "Comprehensive DNA microarray analysis of Bacillus subtilis two-component
RT regulatory systems.";
RL J. Bacteriol. 183:7365-7370(2001).
CC -!- FUNCTION: Member of the two-component regulatory system DctS/DctR.
CC Essential for expression of dctP. {ECO:0000269|PubMed:10708364,
CC ECO:0000269|PubMed:11717295}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated by DctS. {ECO:0000305}.
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DR EMBL; AB001488; BAA19283.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12253.1; -; Genomic_DNA.
DR EMBL; U82580; AAB41751.1; -; Genomic_DNA.
DR PIR; B69771; B69771.
DR RefSeq; NP_388327.1; NC_000964.3.
DR RefSeq; WP_003234347.1; NZ_JNCM01000031.1.
DR AlphaFoldDB; P96602; -.
DR SMR; P96602; -.
DR STRING; 224308.BSU04460; -.
DR PaxDb; P96602; -.
DR PRIDE; P96602; -.
DR EnsemblBacteria; CAB12253; CAB12253; BSU_04460.
DR GeneID; 940148; -.
DR KEGG; bsu:BSU04460; -.
DR PATRIC; fig|224308.179.peg.472; -.
DR eggNOG; COG4565; Bacteria.
DR InParanoid; P96602; -.
DR OMA; MRHGALQ; -.
DR PhylomeDB; P96602; -.
DR BioCyc; BSUB:BSU04460-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001034; DeoR_HTH.
DR InterPro; IPR024187; Sig_transdc_resp-reg_cit/mal.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45526; PTHR45526; 1.
DR Pfam; PF08220; HTH_DeoR; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PIRSF; PIRSF006171; RR_citrat_malat; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..226
FT /note="Probable C4-dicarboxylate response regulator DctR"
FT /id="PRO_0000081092"
FT DOMAIN 7..123
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 179..198
FT /note="H-T-H motif"
FT /evidence="ECO:0000255"
FT MOD_RES 58
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT CONFLICT 24
FT /note="F -> I (in Ref. 3; AAB41751)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 226 AA; 25539 MW; 018115B14E9EF47D CRC64;
MARKEWKVLL IEDDPMVQEV NKDFITTVKG VTVCATAGNG EEGMKLIKEE QPDLVILDVY
MPKKDGIKTL QEIRKQKLEV DVIVVSAAKD KETISLMLQN GAVDYILKPF KLERMRQALE
KYKQYKQKIE ANDTLSQEQL DAILNIPQQA VQDLPKGLNH FTMNEVTAFL KQQTASLSAE
EVAKALGIAR VTARRYLDYL EKTGIIKLDV QYGGVGRPVN RYVLKG
