ID   DCTR_ECO57              Reviewed;         176 AA.
AC   Q8X5P3; Q7AA19;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=HTH-type transcriptional regulator DctR;
GN   Name=dctR; OrderedLocusNames=Z4909, ECs4378;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   FUNCTION.
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=12704134; DOI=10.1128/iai.71.5.2598-2606.2003;
RA   Tatsuno I., Nagano K., Taguchi K., Rong L., Mori H., Sasakawa C.;
RT   "Increased adherence to Caco-2 cells caused by disruption of the yhiE and
RT   yhiF genes in enterohemorrhagic Escherichia coli O157:H7.";
RL   Infect. Immun. 71:2598-2606(2003).
CC   -!- FUNCTION: May act as a transcriptional regulator of dctA (By
CC       similarity). Could be involved in the regulation of the genes coding
CC       for the type III secretion system in enterohaemorragic strains.
CC       {ECO:0000250, ECO:0000269|PubMed:12704134}.
CC   -!- INDUCTION: By acidic conditions. Could be induced by EvgA via the
CC       induction of YdeO (By similarity). {ECO:0000250}.
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DR   EMBL; AE005174; AAG58639.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37801.1; -; Genomic_DNA.
DR   PIR; B91176; B91176.
DR   PIR; C86022; C86022.
DR   RefSeq; NP_312405.1; NC_002695.1.
DR   RefSeq; WP_000478621.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8X5P3; -.
DR   SMR; Q8X5P3; -.
DR   STRING; 155864.EDL933_4746; -.
DR   EnsemblBacteria; AAG58639; AAG58639; Z4909.
DR   EnsemblBacteria; BAB37801; BAB37801; ECs_4378.
DR   GeneID; 66672609; -.
DR   GeneID; 915765; -.
DR   KEGG; ece:Z4909; -.
DR   KEGG; ecs:ECs_4378; -.
DR   PATRIC; fig|386585.9.peg.4574; -.
DR   eggNOG; COG2197; Bacteria.
DR   HOGENOM; CLU_1522929_0_0_6; -.
DR   OMA; QMQTEDI; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..176
FT                   /note="HTH-type transcriptional regulator DctR"
FT                   /id="PRO_0000184147"
FT   DOMAIN          109..174
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        133..152
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   176 AA;  20451 MW;  F1E35D5A3B82BB8C CRC64;
     MFLIITRDTM FFTAMKNILS KGNVVHIQNE EEIDVMLHQN AFVIIDTLMN NVFHSNFLTQ
     IERLKPVHVI IFSPFNIKRC LGKVPVTFVP RTITIIDFVA LINGSYCSVP EANVSLSRKQ
     HQVLSCIANQ MTTEDILEKL KISLKTFYCH KHNIMMILNL KRINELVRHQ HIDYLV