DCTR_ECOLI
ID DCTR_ECOLI Reviewed; 176 AA.
AC P37195; Q2M7G9;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=HTH-type transcriptional regulator DctR;
GN Name=dctR; Synonyms=yhiF; OrderedLocusNames=b3507, JW3475;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=8022277; DOI=10.1111/j.1365-2958.1994.tb00383.x;
RA Alexander D.M., St John A.C.;
RT "Characterization of the carbon starvation-inducible and stationary phase-
RT inducible gene slp encoding an outer membrane lipoprotein in Escherichia
RT coli.";
RL Mol. Microbiol. 11:1059-1071(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT from 76.0 to 81.5 minutes.";
RL Nucleic Acids Res. 22:2576-2586(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP FUNCTION, AND GENE NAME.
RC STRAIN=K12;
RX PubMed=9811641; DOI=10.1128/jb.180.22.5855-5859.1998;
RA Boogerd F.C., Boe L., Michelsen O., Jensen P.R.;
RT "atp mutants of Escherichia coli fail to grow on succinate due to a
RT transport deficiency.";
RL J. Bacteriol. 180:5855-5859(1998).
RN [6]
RP INDUCTION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=12399493; DOI=10.1128/jb.184.22.6225-6234.2002;
RA Masuda N., Church G.M.;
RT "Escherichia coli gene expression responsive to levels of the response
RT regulator EvgA.";
RL J. Bacteriol. 184:6225-6234(2002).
RN [7]
RP INVOLVEMENT IN BIOFILM FORMATION.
RX PubMed=12900028; DOI=10.1016/s0378-1097(03)00507-x;
RA Tenorio E., Saeki T., Fujita K., Kitakawa M., Baba T., Mori H., Isono K.;
RT "Systematic characterization of Escherichia coli genes/ORFs affecting
RT biofilm formation.";
RL FEMS Microbiol. Lett. 225:107-114(2003).
RN [8]
RP INDUCTION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=12694615; DOI=10.1046/j.1365-2958.2003.03477.x;
RA Masuda N., Church G.M.;
RT "Regulatory network of acid resistance genes in Escherichia coli.";
RL Mol. Microbiol. 48:699-712(2003).
CC -!- FUNCTION: May act as a transcriptional regulator of dctA.
CC {ECO:0000269|PubMed:9811641}.
CC -!- INTERACTION:
CC P37195; P0DMC7: rcsB; NbExp=3; IntAct=EBI-562540, EBI-369670;
CC -!- INDUCTION: By acidic conditions. Could be induced by EvgA via the
CC induction of YdeO. {ECO:0000269|PubMed:12399493,
CC ECO:0000269|PubMed:12694615}.
CC -!- MISCELLANEOUS: Overexpression causes filamentous biofilm formation.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L23635; AAA60371.1; -; Genomic_DNA.
DR EMBL; U00039; AAB18483.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76532.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77787.1; -; Genomic_DNA.
DR PIR; S47727; S47727.
DR RefSeq; NP_417964.1; NC_000913.3.
DR RefSeq; WP_000478619.1; NZ_SSZK01000042.1.
DR AlphaFoldDB; P37195; -.
DR SMR; P37195; -.
DR BioGRID; 4261143; 13.
DR BioGRID; 852329; 1.
DR DIP; DIP-12362N; -.
DR IntAct; P37195; 10.
DR STRING; 511145.b3507; -.
DR jPOST; P37195; -.
DR PaxDb; P37195; -.
DR PRIDE; P37195; -.
DR EnsemblBacteria; AAC76532; AAC76532; b3507.
DR EnsemblBacteria; BAE77787; BAE77787; BAE77787.
DR GeneID; 948021; -.
DR KEGG; ecj:JW3475; -.
DR KEGG; eco:b3507; -.
DR PATRIC; fig|1411691.4.peg.3212; -.
DR EchoBASE; EB1835; -.
DR eggNOG; COG2197; Bacteria.
DR HOGENOM; CLU_1522929_0_0_6; -.
DR OMA; QMQTEDI; -.
DR BioCyc; EcoCyc:EG11889-MON; -.
DR PRO; PR:P37195; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:1990451; P:cellular stress response to acidic pH; IMP:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF00196; GerE; 1.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..176
FT /note="HTH-type transcriptional regulator DctR"
FT /id="PRO_0000184145"
FT DOMAIN 109..174
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT DNA_BIND 133..152
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT CONFLICT 163..176
FT /note="INELVRHQHIDYLV -> DQ (in Ref. 1; AAA60371)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 176 AA; 20408 MW; F87354C3AB82BB83 CRC64;
MFLIITRDTM FFTAMKNILS KGNVVHIQNE EEIDVMLHQN AFVIIDTLMN NVFHSNFLTQ
IERLKPVHVI IFSPFNIKRC LGKVPVTFVP RTITIIDFVA LINGSYCSVP EAAVSLSRKQ
HQVLSCIANQ MTTEDILEKL KISLKTFYCH KHNIMMILNL KRINELVRHQ HIDYLV
