ID   DCTR_SHIFL              Reviewed;         176 AA.
AC   Q83J60; Q7UAW3;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=HTH-type transcriptional regulator DctR;
GN   Name=dctR; OrderedLocusNames=SF3541, S4226;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: May act as a transcriptional regulator of dctA.
CC       {ECO:0000250}.
CC   -!- INDUCTION: By acidic conditions. Could be induced by EvgA via the
CC       induction of YdeO (By similarity). {ECO:0000250}.
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DR   EMBL; AE005674; AAN44997.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP19189.1; -; Genomic_DNA.
DR   RefSeq; NP_709290.2; NC_004337.2.
DR   RefSeq; WP_000478623.1; NZ_WPGW01000225.1.
DR   AlphaFoldDB; Q83J60; -.
DR   SMR; Q83J60; -.
DR   STRING; 198214.SF3541; -.
DR   EnsemblBacteria; AAN44997; AAN44997; SF3541.
DR   EnsemblBacteria; AAP19189; AAP19189; S4226.
DR   GeneID; 1026401; -.
DR   GeneID; 58463709; -.
DR   KEGG; sfl:SF3541; -.
DR   KEGG; sfx:S4226; -.
DR   PATRIC; fig|198214.7.peg.4170; -.
DR   HOGENOM; CLU_1522929_0_0_6; -.
DR   OMA; QMQTEDI; -.
DR   OrthoDB; 1236872at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..176
FT                   /note="HTH-type transcriptional regulator DctR"
FT                   /id="PRO_0000184148"
FT   DOMAIN          109..174
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        133..152
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   176 AA;  20437 MW;  302A6CD0132031BD CRC64;
     MFLIITRDTM FFTAMKNILS KGNVVHIQNE EEIDVMLHQN AFVIIDTLMN NVFHSNFLTQ
     IERLKPVHVI VFSPFNIKRC LGKVPVTFVP RTITIIDFVA LINGSYCSVP EANVSLSRKQ
     HQVLSCIANQ MTTEDILEKL KISLKTFYCH KHNIMMILNL KRINELVRHQ HIDYLV