ID   DCUA_HELPJ              Reviewed;         443 AA.
AC   Q9ZLC0;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Anaerobic C4-dicarboxylate transporter DcuA;
GN   Name=dcuA; OrderedLocusNames=jhp_0660;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Responsible for the transport of C4-dicarboxylates from the
CC       periplasm across the inner membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
CC       {ECO:0000305}.
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DR   EMBL; AE001439; AAD06239.1; -; Genomic_DNA.
DR   PIR; C71904; C71904.
DR   AlphaFoldDB; Q9ZLC0; -.
DR   STRING; 85963.jhp_0660; -.
DR   EnsemblBacteria; AAD06239; AAD06239; jhp_0660.
DR   KEGG; hpj:jhp_0660; -.
DR   eggNOG; COG2704; Bacteria.
DR   OMA; PKQINYL; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015556; F:C4-dicarboxylate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR004668; Anaer_Dcu_memb_transpt.
DR   PANTHER; PTHR36106; PTHR36106; 1.
DR   Pfam; PF03605; DcuA_DcuB; 1.
DR   PIRSF; PIRSF004539; C4-dicrbxl_trns; 1.
DR   TIGRFAMs; TIGR00770; Dcu; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..443
FT                   /note="Anaerobic C4-dicarboxylate transporter DcuA"
FT                   /id="PRO_0000170351"
FT   TRANSMEM        1..20
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        21
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        22..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        41..56
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        57..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        75..88
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        89..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        107..135
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        136..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        151..231
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        232..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        250..267
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        268..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        286..295
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        296..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        314..335
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        336..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        354..358
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        359..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        384..443
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   443 AA;  47292 MW;  ECD39D533B250449 CRC64;
     MVDAFFQIIV LLFSLFLGAR LGGLGVGYAG GLGVLILCLF LGLNPGKIPF DVILIIMAVI
     SAISAMQKAG GLDYLVQIAE KILRKHPKQI NYLAPSVAYF LTILAGTGHT VFSLIPVIVE
     VSQSQNIKPK APLSLAVVSS QVAITASPVS AAVVFMSGIL EPLGADYLTL LMVWIPTTFL
     ACMLTAFVMG FTDLKLDSDP NYLERLKAGK ISPPMMKKEK ETSKSAKLSL WIFIGGVVAI
     VFYASAISKN IALISPVILG RDYAIVSFML SVATLIAIFC KINANEIAHS SVFKSGMQAC
     VCVLGVAWLG DTFVSNHIDE IKRYASFLIA DYPFLLAVAL FLASMLLYSQ AATSKALIPS
     VITALGISAN HTEHLYIIVA SFASVSALFV LPTYPTLLGA IAMDHTGTTK MGRYVFDHAF
     LIPGVLVVFL SVALGFVVAP LVL