DCUA_HELPY
ID DCUA_HELPY Reviewed; 443 AA.
AC O25425;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Anaerobic C4-dicarboxylate transporter DcuA;
GN Name=dcuA; OrderedLocusNames=HP_0724;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: Responsible for the transport of C4-dicarboxylates from the
CC periplasm across the inner membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
CC {ECO:0000305}.
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DR EMBL; AE000511; AAD07773.1; -; Genomic_DNA.
DR PIR; D64610; D64610.
DR RefSeq; NP_207518.1; NC_000915.1.
DR RefSeq; WP_000227192.1; NC_018939.1.
DR AlphaFoldDB; O25425; -.
DR STRING; 85962.C694_03725; -.
DR PaxDb; O25425; -.
DR EnsemblBacteria; AAD07773; AAD07773; HP_0724.
DR KEGG; hpy:HP_0724; -.
DR PATRIC; fig|85962.47.peg.773; -.
DR eggNOG; COG2704; Bacteria.
DR OMA; PKQINYL; -.
DR PhylomeDB; O25425; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015556; F:C4-dicarboxylate transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR004668; Anaer_Dcu_memb_transpt.
DR PANTHER; PTHR36106; PTHR36106; 1.
DR Pfam; PF03605; DcuA_DcuB; 1.
DR PIRSF; PIRSF004539; C4-dicrbxl_trns; 1.
DR TIGRFAMs; TIGR00770; Dcu; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..443
FT /note="Anaerobic C4-dicarboxylate transporter DcuA"
FT /id="PRO_0000170350"
FT TRANSMEM 1..20
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 22..40
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 41..56
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 57..74
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 75..88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 89..106
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 107..135
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 136..150
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 151..231
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 232..249
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 250..267
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 268..285
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 286..295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 296..313
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 314..335
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 336..353
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 354..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 359..383
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 384..443
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 443 AA; 47173 MW; 0E693630A0B50141 CRC64;
MVDAFFQIAV LLFSLFLGAR LGGLGVGYAG GLGVLILCLF LGLNPGKIPF DVILIIMAVI
SAISAMQKAG GLDYLVKIAE KILRKHPKQI NYLAPSVAYC LTILAGTGHT VFSLIPVIVE
VSQSQNIKPK APLSLAVVSS QVAITASPVS AAVVFMSGIL EPLGANYLTL LMVWIPTTFL
ACMLTAFIMG FTDLKLDSDP HYLERLKAGK ISPPKIKEEK ETSKNAKLSL WIFIGGVVAI
VFYASAISKN IAFVSPVVLG RDHAIVSFML SVATLIVLFC KINANEIAHS SVFKSGMQAC
VCVLGVAWLG DTFVSNHIDE IKRYASFLIA DYPFLLAVAL FLASMLLYSQ AATSKALIPS
VITALGISAN HTEHLYIIVA SFASVSALFV LPTYPTLLGA IAMDNTGTTK MGRYVFDHAF
LIPGVLVVSL SVALGFVVAP LVL