DCUA_SHIFL
ID DCUA_SHIFL Reviewed; 433 AA.
AC P0ABN8; P04539;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Anaerobic C4-dicarboxylate transporter DcuA;
GN Name=dcuA; OrderedLocusNames=SF4292, S4559;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Responsible for the transport of C4-dicarboxylates from the
CC periplasm across the inner membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
CC {ECO:0000305}.
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DR EMBL; AE005674; AAN45710.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP19496.1; -; Genomic_DNA.
DR RefSeq; NP_710003.1; NC_004337.2.
DR RefSeq; WP_000961959.1; NZ_WPGW01000108.1.
DR AlphaFoldDB; P0ABN8; -.
DR STRING; 198214.SF4292; -.
DR EnsemblBacteria; AAN45710; AAN45710; SF4292.
DR EnsemblBacteria; AAP19496; AAP19496; S4559.
DR GeneID; 1027378; -.
DR GeneID; 67414756; -.
DR KEGG; sfl:SF4292; -.
DR KEGG; sfx:S4559; -.
DR PATRIC; fig|198214.7.peg.5062; -.
DR HOGENOM; CLU_036056_1_1_6; -.
DR OMA; PKQINYL; -.
DR OrthoDB; 591678at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015556; F:C4-dicarboxylate transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR004668; Anaer_Dcu_memb_transpt.
DR PANTHER; PTHR36106; PTHR36106; 1.
DR Pfam; PF03605; DcuA_DcuB; 1.
DR PIRSF; PIRSF004539; C4-dicrbxl_trns; 1.
DR TIGRFAMs; TIGR00770; Dcu; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..433
FT /note="Anaerobic C4-dicarboxylate transporter DcuA"
FT /id="PRO_0000170353"
FT TRANSMEM 1..18
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 38..53
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 54..71
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 72..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 86..103
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 104..132
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 133..147
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 148..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 229..246
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 247..264
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 265..282
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 283..292
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 293..310
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 311..332
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 333..350
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 351..355
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 356..373
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 374..433
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 433 AA; 45751 MW; 049C8D186C83C9AD CRC64;
MLVVELIIVL LAIFLGARLG GIGIGFAGGL GVLVLAAIGV KPGNIPFDVI SIIMAVIAAI
SAMQVAGGLD YLVHQTEKLL RRNPKYITIL APIVTYFLTI FAGTGNISLA TLPVIAEVAK
EQGVKPCRPL STAVVSAQIA ITASPISAAV VYMSSVMEGH GISYLHLLSV VIPSTLLAVL
VMSFLVTMLF NSKLSDDPIY RKRLEEGLVE LRGEKQIEIK SGAKTSVWLF LLGVVGVVIY
AIINSPSMGL VEKPLMNTTN AILIIMLSVA TLTTVICKVD TDNILNSSTF KAGMSACICI
LGVAWLGDTF VSNNIDWIKD TAGEVIQGHP WLLAVIFFFA SALLYSQAAT AKALMPMALA
LNVSPLTAVA SFAAVSGLFI LPTYPTLVAA VQMDDTGTTR IGKFVFNHPF FIPGTLGVAL
AVCFGFVLGS FML
