DCUB_ECO57
ID DCUB_ECO57 Reviewed; 446 AA.
AC P0ABP1; P14409;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Anaerobic C4-dicarboxylate transporter DcuB;
GN Name=dcuB; OrderedLocusNames=Z5725, ECs5105;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Responsible for the transport of C4-dicarboxylates from the
CC periplasm across the inner membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE005174; AAG59322.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB38528.1; -; Genomic_DNA.
DR PIR; A91267; A91267.
DR PIR; F86107; F86107.
DR RefSeq; NP_313132.1; NC_002695.1.
DR RefSeq; WP_000899522.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P0ABP1; -.
DR STRING; 155864.EDL933_5469; -.
DR EnsemblBacteria; AAG59322; AAG59322; Z5725.
DR EnsemblBacteria; BAB38528; BAB38528; ECs_5105.
DR GeneID; 66671966; -.
DR GeneID; 914219; -.
DR KEGG; ece:Z5725; -.
DR KEGG; ecs:ECs_5105; -.
DR PATRIC; fig|386585.9.peg.5335; -.
DR eggNOG; COG2704; Bacteria.
DR HOGENOM; CLU_036056_1_1_6; -.
DR OMA; DKDPEFQ; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015556; F:C4-dicarboxylate transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR004668; Anaer_Dcu_memb_transpt.
DR PANTHER; PTHR36106; PTHR36106; 1.
DR Pfam; PF03605; DcuA_DcuB; 1.
DR PIRSF; PIRSF004539; C4-dicrbxl_trns; 1.
DR TIGRFAMs; TIGR00770; Dcu; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..446
FT /note="Anaerobic C4-dicarboxylate transporter DcuB"
FT /id="PRO_0000170356"
FT TRANSMEM 1..19
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 40..55
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 56..73
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 74..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 88..105
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 106..134
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 135..149
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 150..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 241..258
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 259..275
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 276..293
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 294..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 304..321
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 322..343
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 344..361
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 362..366
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 367..384
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 385..446
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT CONFLICT 214
FT /note="E -> K (in Ref. 1; AAG59322)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 446 AA; 47935 MW; B4AF89BB2E0CCB3B CRC64;
MLFTIQLIII LICLFYGARK GGIALGLLGG IGLVILVFVF HLQPGKPPVD VMLVIIAVVA
ASATLQASGG LDVMLQIAEK LLRRNPKYVS IVAPFVTCTL TILCGTGHVV YTILPIIYDV
AIKNNIRPER PMAASSIGAQ MGIIASPVSV AVVSLVAMLG NVTFDGRHLE FLDLLAITIP
STLIGILAIG IFSWFRGKDL DKDEEFQKFI SVPENREYVY GDTATLLDKK LPKSNWLAMW
IFLGAIAVVA LLGADSDLRP SFGGKPLSMV LVIQMFMLLT GALIIILTKT NPASISKNEV
FRSGMIAIVA VYGIAWMAET MFGAHMSEIQ GVLGEMVKEY PWAYAIVLLL VSKFVNSQAA
ALAAIVPVAL AIGVDPAYIV ASAPACYGYY ILPTYPSDLA AIQFDRSGTT HIGRFVINHS
FILPGLIGVS VSCVFGWIFA AMYGFL
