ID   DCUB_ECOL6              Reviewed;         446 AA.
AC   P0ABP0; P14409;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Anaerobic C4-dicarboxylate transporter DcuB;
GN   Name=dcuB; OrderedLocusNames=c5128;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Responsible for the transport of C4-dicarboxylates from the
CC       periplasm across the inner membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE014075; AAN83550.1; -; Genomic_DNA.
DR   RefSeq; WP_000899522.1; NC_004431.1.
DR   AlphaFoldDB; P0ABP0; -.
DR   STRING; 199310.c5128; -.
DR   EnsemblBacteria; AAN83550; AAN83550; c5128.
DR   GeneID; 66671966; -.
DR   KEGG; ecc:c5128; -.
DR   eggNOG; COG2704; Bacteria.
DR   HOGENOM; CLU_036056_1_1_6; -.
DR   OMA; DKDPEFQ; -.
DR   BioCyc; ECOL199310:C5128-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015556; F:C4-dicarboxylate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR004668; Anaer_Dcu_memb_transpt.
DR   PANTHER; PTHR36106; PTHR36106; 1.
DR   Pfam; PF03605; DcuA_DcuB; 1.
DR   PIRSF; PIRSF004539; C4-dicrbxl_trns; 1.
DR   TIGRFAMs; TIGR00770; Dcu; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..446
FT                   /note="Anaerobic C4-dicarboxylate transporter DcuB"
FT                   /id="PRO_0000170357"
FT   TRANSMEM        1..19
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        21..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        40..55
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        56..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        74..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        88..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        106..134
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        135..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        150..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        241..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        259..275
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        276..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        294..303
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        304..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        322..343
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        344..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        362..366
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        367..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        385..446
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   446 AA;  47935 MW;  B4AF89BB2E0CCB3B CRC64;
     MLFTIQLIII LICLFYGARK GGIALGLLGG IGLVILVFVF HLQPGKPPVD VMLVIIAVVA
     ASATLQASGG LDVMLQIAEK LLRRNPKYVS IVAPFVTCTL TILCGTGHVV YTILPIIYDV
     AIKNNIRPER PMAASSIGAQ MGIIASPVSV AVVSLVAMLG NVTFDGRHLE FLDLLAITIP
     STLIGILAIG IFSWFRGKDL DKDEEFQKFI SVPENREYVY GDTATLLDKK LPKSNWLAMW
     IFLGAIAVVA LLGADSDLRP SFGGKPLSMV LVIQMFMLLT GALIIILTKT NPASISKNEV
     FRSGMIAIVA VYGIAWMAET MFGAHMSEIQ GVLGEMVKEY PWAYAIVLLL VSKFVNSQAA
     ALAAIVPVAL AIGVDPAYIV ASAPACYGYY ILPTYPSDLA AIQFDRSGTT HIGRFVINHS
     FILPGLIGVS VSCVFGWIFA AMYGFL