ID   DCUB_HAEIN              Reviewed;         440 AA.
AC   P44855;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Anaerobic C4-dicarboxylate transporter DcuB;
GN   Name=dcuB; OrderedLocusNames=HI_0746;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Responsible for the transport of C4-dicarboxylates from the
CC       periplasm across the inner membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22404.1; -; Genomic_DNA.
DR   PIR; B64090; B64090.
DR   RefSeq; NP_438905.1; NC_000907.1.
DR   RefSeq; WP_005655513.1; NC_000907.1.
DR   AlphaFoldDB; P44855; -.
DR   STRING; 71421.HI_0746; -.
DR   EnsemblBacteria; AAC22404; AAC22404; HI_0746.
DR   KEGG; hin:HI_0746; -.
DR   PATRIC; fig|71421.8.peg.783; -.
DR   eggNOG; COG2704; Bacteria.
DR   HOGENOM; CLU_036056_1_1_6; -.
DR   OMA; KIGKYIF; -.
DR   PhylomeDB; P44855; -.
DR   BioCyc; HINF71421:G1GJ1-784-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015556; F:C4-dicarboxylate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR004668; Anaer_Dcu_memb_transpt.
DR   PANTHER; PTHR36106; PTHR36106; 1.
DR   Pfam; PF03605; DcuA_DcuB; 1.
DR   PIRSF; PIRSF004539; C4-dicrbxl_trns; 1.
DR   TIGRFAMs; TIGR00770; Dcu; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..440
FT                   /note="Anaerobic C4-dicarboxylate transporter DcuB"
FT                   /id="PRO_0000170359"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        22
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        23..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        42..57
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        58..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        76..89
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        90..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        108..136
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        137..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        152..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        237..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        255..271
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        272..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        290..299
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        300..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        318..339
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        340..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        358..362
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        363..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        381..440
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   440 AA;  46557 MW;  84AFF11D4712F9C0 CRC64;
     MSAMFLLQFA IVLLCIFVGA RVGGIGLGVF GGLGLAILSF GFGLKPAGLP IDVMFMIMAV
     VAAAAAMQAA GGLDYMIKIA TKILRRNPKH ITFIAPAVTW LFTLLAGTGH VAYSVLPVIA
     EVSRQNGIRP ERPMSMAVIA SQFAIVASPI AAAVVAVVAY LEPQGIHLGD VLMVTIPSTI
     LGLFLACLFV NKMGKELKDD PEYQRRLNDP KYADIFASTT SVKEVEVSKT AKISVSLFLF
     GALLVVLMGA APSIRPVFDG KPMGMAHTIE IIMLSIGALI ILTCKPDGTA ITKGSVFHAG
     MRAVIAIFGI AWLGDTLMQA HITEVKEMVK GLVETAPWAF AFALFVLSVL VNSQGATVAT
     LFPLGIALGI PAPVLIGVFV AVNGYFFIPN YGPIIASLDF DTTGTTKIGK YILNHSFMLP
     GLLSMFFCLL IGLGLSHVIL