DCUB_SHIFL
ID DCUB_SHIFL Reviewed; 446 AA.
AC P0ABP2; P14409;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Anaerobic C4-dicarboxylate transporter DcuB;
GN Name=dcuB; OrderedLocusNames=SF4100, S3630;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Responsible for the transport of C4-dicarboxylates from the
CC periplasm across the inner membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
CC {ECO:0000305}.
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DR EMBL; AE005674; AAN45525.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP18674.1; -; Genomic_DNA.
DR RefSeq; NP_709818.1; NC_004337.2.
DR RefSeq; WP_000899522.1; NZ_WPGW01000049.1.
DR AlphaFoldDB; P0ABP2; -.
DR STRING; 198214.SF4100; -.
DR EnsemblBacteria; AAN45525; AAN45525; SF4100.
DR EnsemblBacteria; AAP18674; AAP18674; S3630.
DR GeneID; 1027759; -.
DR GeneID; 66671966; -.
DR KEGG; sfl:SF4100; -.
DR KEGG; sfx:S3630; -.
DR PATRIC; fig|198214.7.peg.4834; -.
DR HOGENOM; CLU_036056_1_1_6; -.
DR OMA; DKDPEFQ; -.
DR OrthoDB; 591678at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015556; F:C4-dicarboxylate transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR004668; Anaer_Dcu_memb_transpt.
DR PANTHER; PTHR36106; PTHR36106; 1.
DR Pfam; PF03605; DcuA_DcuB; 1.
DR PIRSF; PIRSF004539; C4-dicrbxl_trns; 1.
DR TIGRFAMs; TIGR00770; Dcu; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..446
FT /note="Anaerobic C4-dicarboxylate transporter DcuB"
FT /id="PRO_0000170358"
FT TRANSMEM 1..19
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 40..55
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 56..73
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 74..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 88..105
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 106..134
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 135..149
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 150..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 241..258
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 259..275
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 276..293
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 294..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 304..321
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 322..343
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 344..361
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 362..366
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 367..384
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 385..446
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 446 AA; 47935 MW; B4AF89BB2E0CCB3B CRC64;
MLFTIQLIII LICLFYGARK GGIALGLLGG IGLVILVFVF HLQPGKPPVD VMLVIIAVVA
ASATLQASGG LDVMLQIAEK LLRRNPKYVS IVAPFVTCTL TILCGTGHVV YTILPIIYDV
AIKNNIRPER PMAASSIGAQ MGIIASPVSV AVVSLVAMLG NVTFDGRHLE FLDLLAITIP
STLIGILAIG IFSWFRGKDL DKDEEFQKFI SVPENREYVY GDTATLLDKK LPKSNWLAMW
IFLGAIAVVA LLGADSDLRP SFGGKPLSMV LVIQMFMLLT GALIIILTKT NPASISKNEV
FRSGMIAIVA VYGIAWMAET MFGAHMSEIQ GVLGEMVKEY PWAYAIVLLL VSKFVNSQAA
ALAAIVPVAL AIGVDPAYIV ASAPACYGYY ILPTYPSDLA AIQFDRSGTT HIGRFVINHS
FILPGLIGVS VSCVFGWIFA AMYGFL
