DCUC_ECO57
ID DCUC_ECO57 Reviewed; 461 AA.
AC P0ABP4; Q47134; Q9ZBC9; Q9ZBD0;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Anaerobic C4-dicarboxylate transporter DcuC;
GN Name=dcuC; OrderedLocusNames=Z0766, ECs0660;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Responsible for the transport of C4-dicarboxylates during
CC anaerobic growth. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
CC {ECO:0000305}.
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DR EMBL; AE005174; AAG54956.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB34083.1; -; Genomic_DNA.
DR PIR; D90711; D90711.
DR PIR; H85561; H85561.
DR RefSeq; NP_308687.1; NC_002695.1.
DR RefSeq; WP_000955063.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P0ABP4; -.
DR SMR; P0ABP4; -.
DR STRING; 155864.EDL933_0694; -.
DR EnsemblBacteria; AAG54956; AAG54956; Z0766.
DR EnsemblBacteria; BAB34083; BAB34083; ECs_0660.
DR GeneID; 917020; -.
DR KEGG; ece:Z0766; -.
DR KEGG; ecs:ECs_0660; -.
DR PATRIC; fig|386585.9.peg.771; -.
DR eggNOG; COG3069; Bacteria.
DR HOGENOM; CLU_030262_3_2_6; -.
DR OMA; DVAYRGM; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015556; F:C4-dicarboxylate transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR004669; C4_dicarb_anaerob_car.
DR InterPro; IPR018385; C4_dicarb_anaerob_car-like.
DR PANTHER; PTHR42002; PTHR42002; 1.
DR Pfam; PF03606; DcuC; 1.
DR TIGRFAMs; TIGR00771; DcuC; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..461
FT /note="Anaerobic C4-dicarboxylate transporter DcuC"
FT /id="PRO_0000201628"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 461 AA; 48412 MW; D4042FBFE9F562ED CRC64;
MLTFIELLIG VVVIVGVARY IIKGYSATGV LFVGGLLLLI ISAIMGHKVL PSSQASTGYS
ATDIVEYVKI LLMSRGGDLG MMIMMLCGFA AYMTHIGAND MVVKLASKPL QYINSPYLLM
IAAYFVACLM SLAVSSATGL GVLLMATLFP VMVNVGISRG AAAAICASPA AIILAPTSGD
VVLAAQASEM SLIDFAFKTT LPISIAAIIG MAIAHFFWQR YLDKKEHISH EMLDVSEITT
TAPAFYAILP FTPIIGVLIF DGKWGPQLHI ITILVICMLI ASILEFLRSF NTQKVFSGLE
VAYRGMADAF ANVVMLLVAA GVFAQGLSTI GFIQSLISIA TSFGSASIIL MLVLVILTML
AAVTTGSGNA PFYAFVEMIP KLAHSSGINP AYLTIPMLQA SNLGRTLSPV SGVVVAVAGM
AKISPFEVVK RTSVPVLVGL VIVIVATELM VPGTAAAVTG K