DCUC_ECOLI
ID DCUC_ECOLI Reviewed; 461 AA.
AC P0ABP3; Q47134; Q9ZBC9; Q9ZBD0;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Anaerobic C4-dicarboxylate transporter DcuC;
GN Name=dcuC; OrderedLocusNames=b0621, JW0613/JW0616;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / AN387;
RX PubMed=8955408; DOI=10.1128/jb.178.24.7241-7247.1996;
RA Zientz E., Six S., Unden G.;
RT "Identification of a third secondary carrier (DcuC) for anaerobic C4-
RT dicarboxylate transport in Escherichia coli: roles of the three Dcu
RT carriers in uptake and exchange.";
RL J. Bacteriol. 178:7241-7247(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP FUNCTION.
RC STRAIN=K12 / AN387;
RX PubMed=10368146; DOI=10.1128/jb.181.12.3716-3720.1999;
RA Zientz E., Janausch I.G., Six S., Unden G.;
RT "Functioning of DcuC as the C4-dicarboxylate carrier during glucose
RT fermentation by Escherichia coli.";
RL J. Bacteriol. 181:3716-3720(1999).
RN [7]
RP SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Responsible for the transport of C4-dicarboxylates during
CC anaerobic growth. {ECO:0000269|PubMed:10368146}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15919996}.
CC -!- SIMILARITY: Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
CC {ECO:0000305}.
CC -!- CAUTION: PubMed:8905232 and PubMed:16738553 sequences differ from that
CC shown due to the presence of an IS5 insertion element between codons
CC 327 and 328. Strain W3110A but not W3110B harbors this IS5 insertion.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA35263.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X99112; CAA67561.1; -; Genomic_DNA.
DR EMBL; U82598; AAB40821.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73722.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35264.1; ALT_TERM; Genomic_DNA.
DR EMBL; AP009048; BAA35263.1; ALT_INIT; Genomic_DNA.
DR PIR; C64796; C64796.
DR RefSeq; NP_415154.1; NC_000913.3.
DR RefSeq; WP_000955063.1; NZ_STEB01000031.1.
DR AlphaFoldDB; P0ABP3; -.
DR SMR; P0ABP3; -.
DR STRING; 511145.b0621; -.
DR TCDB; 2.A.61.1.1; the c4-dicarboxylate uptake c (dcuc) family.
DR PaxDb; P0ABP3; -.
DR PRIDE; P0ABP3; -.
DR EnsemblBacteria; AAC73722; AAC73722; b0621.
DR EnsemblBacteria; BAA35263; BAA35263; BAA35263.
DR EnsemblBacteria; BAA35264; BAA35264; BAA35264.
DR GeneID; 945000; -.
DR KEGG; ecj:JW0613; -.
DR KEGG; ecj:JW0616; -.
DR KEGG; eco:b0621; -.
DR PATRIC; fig|1411691.4.peg.1647; -.
DR EchoBASE; EB3315; -.
DR eggNOG; COG3069; Bacteria.
DR HOGENOM; CLU_030262_2_0_6; -.
DR OMA; DVAYRGM; -.
DR PhylomeDB; P0ABP3; -.
DR BioCyc; EcoCyc:DCUC-MON; -.
DR BioCyc; MetaCyc:DCUC-MON; -.
DR PRO; PR:P0ABP3; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0005469; F:succinate:fumarate antiporter activity; IDA:EcoCyc.
DR GO; GO:0015740; P:C4-dicarboxylate transport; IGI:EcoliWiki.
DR GO; GO:0019664; P:mixed acid fermentation; IEP:EcoCyc.
DR InterPro; IPR004669; C4_dicarb_anaerob_car.
DR InterPro; IPR018385; C4_dicarb_anaerob_car-like.
DR PANTHER; PTHR42002; PTHR42002; 1.
DR Pfam; PF03606; DcuC; 1.
DR TIGRFAMs; TIGR00771; DcuC; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..461
FT /note="Anaerobic C4-dicarboxylate transporter DcuC"
FT /id="PRO_0000201627"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 461 AA; 48412 MW; D4042FBFE9F562ED CRC64;
MLTFIELLIG VVVIVGVARY IIKGYSATGV LFVGGLLLLI ISAIMGHKVL PSSQASTGYS
ATDIVEYVKI LLMSRGGDLG MMIMMLCGFA AYMTHIGAND MVVKLASKPL QYINSPYLLM
IAAYFVACLM SLAVSSATGL GVLLMATLFP VMVNVGISRG AAAAICASPA AIILAPTSGD
VVLAAQASEM SLIDFAFKTT LPISIAAIIG MAIAHFFWQR YLDKKEHISH EMLDVSEITT
TAPAFYAILP FTPIIGVLIF DGKWGPQLHI ITILVICMLI ASILEFLRSF NTQKVFSGLE
VAYRGMADAF ANVVMLLVAA GVFAQGLSTI GFIQSLISIA TSFGSASIIL MLVLVILTML
AAVTTGSGNA PFYAFVEMIP KLAHSSGINP AYLTIPMLQA SNLGRTLSPV SGVVVAVAGM
AKISPFEVVK RTSVPVLVGL VIVIVATELM VPGTAAAVTG K
