ID   DCUC_VIBCH              Reviewed;         459 AA.
AC   Q9KLS6;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Probable anaerobic C4-dicarboxylate transporter DcuC;
GN   Name=dcuC; OrderedLocusNames=VC_A0665;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Responsible for the transport of C4-dicarboxylates during
CC       anaerobic growth. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
CC       {ECO:0000305}.
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DR   EMBL; AE003853; AAF96566.1; -; Genomic_DNA.
DR   PIR; G82431; G82431.
DR   RefSeq; NP_233054.1; NC_002506.1.
DR   AlphaFoldDB; Q9KLS6; -.
DR   STRING; 243277.VC_A0665; -.
DR   DNASU; 2612512; -.
DR   EnsemblBacteria; AAF96566; AAF96566; VC_A0665.
DR   KEGG; vch:VC_A0665; -.
DR   PATRIC; fig|243277.26.peg.3291; -.
DR   eggNOG; COG3069; Bacteria.
DR   HOGENOM; CLU_030262_3_2_6; -.
DR   OMA; DVAYRGM; -.
DR   BioCyc; VCHO:VCA0665-MON; -.
DR   Proteomes; UP000000584; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015556; F:C4-dicarboxylate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015740; P:C4-dicarboxylate transport; IBA:GO_Central.
DR   InterPro; IPR004669; C4_dicarb_anaerob_car.
DR   InterPro; IPR018385; C4_dicarb_anaerob_car-like.
DR   PANTHER; PTHR42002; PTHR42002; 1.
DR   Pfam; PF03606; DcuC; 1.
DR   TIGRFAMs; TIGR00771; DcuC; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..459
FT                   /note="Probable anaerobic C4-dicarboxylate transporter
FT                   DcuC"
FT                   /id="PRO_0000201631"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   459 AA;  48089 MW;  729D5DA83219986F CRC64;
     MEIAMLELLI GLVVTFAVGY FIVKGYKPAG ILLTAGILLL ILTGILGHKV LPGQMESTGN
     LLTDAMEYVK YMLQNRGGGL GMQIMLLCGF ASYMTHIGAN NVVVKQFSKP LSFIKSPYIL
     LVAAYLVACL MSLAVSSATG LGVLLMATLF PMMTAMGISR PAAVAVCASP AAIILSPTSG
     DVVIAAEKSG LPLHVFAVET VLPVSICAII VMAAAAYFWN QYLDKKDNTP MEKVDLSEME
     VKSPAYYAVL PFLPIIGVFV FNGETLPGIT LDIYTIVVLS IFIGVLVDYI TKRFNGKQTL
     EDLEACYEGM ADAFKGVVML LVAAGVFAQG LMSIGAIDNL LHLAEVAGAG GIALMLILTG
     LTVAAAIATG SGNAPFYAFV ELAPSLAAKM GLNPAFLIIP MLQASNLGRT ISPVSGVVVA
     TAGMGKISPF EVVKRTSVPV LLGLVTVIIG TMVLVPMHA