ID   ACT_LEIMA               Reviewed;         376 AA.
AC   P45520;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Actin;
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MHOM/IR/83/Lt252 / CC-1;
RX   PubMed=8112581; DOI=10.1016/0378-1119(94)90534-7;
RA   de Arruda M.V., Matsudaira P.;
RT   "Cloning and sequencing of the Leishmania major actin-encoding gene.";
RL   Gene 139:123-125(1994).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L16961; AAA19789.1; -; Unassigned_DNA.
DR   AlphaFoldDB; P45520; -.
DR   SMR; P45520; -.
DR   STRING; 5664.LmjF.04.1230; -.
DR   VEuPathDB; TriTrypDB:LmjF.04.1230; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_040018100; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_040018400; -.
DR   eggNOG; KOG0676; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   CHAIN           1..376
FT                   /note="Actin"
FT                   /id="PRO_0000088952"
SQ   SEQUENCE   376 AA;  41991 MW;  AB63A52B1EF67028 CRC64;
     MADNEQSSIV CDNGSGMVKA GFSGDDAPRH VFPSIVGRPK NMQAMMGSAN KTVYVGDEAQ
     SKRGVLSLKY PIEHGIVTNW DDMEKIWHHT FYNDVRVNPE QHNVLLTEAP MNPKQNREKM
     TQIMFETFNV PSLYIGIQAV LSLYSSGRTT GIVLDAGDGV THTVPIYEGY SLPHAVRRVD
     MAGRDLTEYL MKIMMETGTT FTTTAEKEIV RNVKEQLCYV ALDFEEEMTN SAKSANEEAF
     ELPDGNVMMV GNQRFRCPEV LFKPSLIGLD EAPGFPEMVY QSINKCDIDV RRELYGNIVL
     SGGSTMFLNL PERLAKEISN LAPSSIKPKV VAPPERKYSV WIGGSILSSL TTFQTMWVKK
     SEYDESGPSI VHNKCF