ID   ACT_NEUCR               Reviewed;         375 AA.
AC   P78711; Q7S7R0; V5IPI2;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Actin;
GN   Name=act; ORFNames=B7A16.050, NCU04173;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9819052; DOI=10.1007/s004380050853;
RA   Tinsley J.H., Lee I.H., Minke P.F., Plamann M.;
RT   "Analysis of actin and actin-related protein 3 (ARP3) gene expression
RT   following induction of hyphal tip formation and apolar growth in
RT   Neurospora.";
RL   Mol. Gen. Genet. 259:601-609(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; U78026; AAC78496.1; -; Genomic_DNA.
DR   EMBL; AL513445; CAC28718.1; -; Genomic_DNA.
DR   EMBL; CM002240; ESA42660.1; -; Genomic_DNA.
DR   EMBL; CM002240; ESA42661.1; -; Genomic_DNA.
DR   RefSeq; XP_011394625.1; XM_011396323.1.
DR   RefSeq; XP_011394626.1; XM_011396324.1.
DR   AlphaFoldDB; P78711; -.
DR   SMR; P78711; -.
DR   STRING; 5141.EFNCRP00000003898; -.
DR   PRIDE; P78711; -.
DR   EnsemblFungi; ESA42660; ESA42660; NCU04173.
DR   EnsemblFungi; ESA42661; ESA42661; NCU04173.
DR   GeneID; 3877297; -.
DR   KEGG; ncr:NCU04173; -.
DR   VEuPathDB; FungiDB:NCU04173; -.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   InParanoid; P78711; -.
DR   OMA; FHTTAER; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..375
FT                   /note="Actin"
FT                   /id="PRO_0000088968"
FT   CONFLICT        40
FT                   /note="H -> Y (in Ref. 1; AAC78496)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        176
FT                   /note="A -> S (in Ref. 1; AAC78496)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        259
FT                   /note="E -> K (in Ref. 1; AAC78496)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   375 AA;  41608 MW;  6732E9178708E425 CRC64;
     MEEEVAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH HGIMIGMGQK DSYVGDEAQS
     KRGILTLRYP IEHGVVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPI NPKSNREKMT
     QIVFETFNAP AFYVSIQAVL SLYASGRTTG IVLDSGDGVT HVVPIYEGFA LPHAIARVDM
     AGRDLTDYLM KILAERGYTF STTAEREIVR DIKEKLCYVA LDFEQEIQTA AQSSSLEKSY
     ELPDGQVITI GNERFRAPEA LFQPSVLGLE SGGIHVTTFN SIMKCDVDVR KDLYGNIVMS
     GGTTMYPGLS DRMQKEITAL APSSMKVKII APPERKYSVW IGGSILASLS TFQQMWISKQ
     EYDESGPSIV HRKCF