ACT_OGAPD
ID ACT_OGAPD Reviewed; 376 AA.
AC O74258; E7R1T4; W1QKS1;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Actin;
GN Name=ACT; ORFNames=HPODL_00818;
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1;
RX PubMed=11525622; DOI=10.1007/s002530100605;
RA Kang H.-A., Hong W.-K., Sohn J.-H., Choi E.-S., Rhee S.-K.;
RT "Molecular characterization of the actin-encoding gene and the use of its
RT promoter for a dominant selection system in the methylotrophic yeast
RT Hansenula polymorpha.";
RL Appl. Microbiol. Biotechnol. 55:734-741(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1;
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
CC -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC various types of cell motility and are ubiquitously expressed in all
CC eukaryotic cells.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF085278; AAC34678.1; -; Genomic_DNA.
DR EMBL; AEOI02000005; ESX01424.1; -; Genomic_DNA.
DR RefSeq; XP_013936258.1; XM_014080783.1.
DR AlphaFoldDB; O74258; -.
DR SMR; O74258; -.
DR STRING; 1005962.O74258; -.
DR PRIDE; O74258; -.
DR EnsemblFungi; ESX01424; ESX01424; HPODL_00818.
DR GeneID; 25770287; -.
DR eggNOG; KOG0676; Eukaryota.
DR HOGENOM; CLU_027965_0_2_1; -.
DR OMA; FHTTAER; -.
DR OrthoDB; 649708at2759; -.
DR Proteomes; UP000008673; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00406; ACTINS_1; 1.
DR PROSITE; PS00432; ACTINS_2; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..376
FT /note="Actin"
FT /id="PRO_0000088990"
FT CONFLICT 58
FT /note="E -> K (in Ref. 1; AAC34678)"
FT /evidence="ECO:0000305"
FT CONFLICT 82..83
FT /note="DM -> NL (in Ref. 1; AAC34678)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 376 AA; 41703 MW; 4AE38CEFF0CB0310 CRC64;
MDGEDVAALV IDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGIMVGMGQ KDSYVGDEAQ
SKRGILTLRY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE EHPVLLTEAP MNPKSNREKM
TQILFETFNV PAFYVSIQAV LSLYSSGRTT GIVLDSGDGV THVVPIYAGF SLPHAILRID
LAGRDLTDYL MKILSERGYT FSTTAEREIV RDIKEKLCYV ALDFDQELQT SSQSSAIEKS
YELPDGQVIT IGNERFRAPE VLFHPGPLGL EAAGIDQTTY NSIIKCDVDV RKELYGNIVM
SGGTTMFPGI AERMQKEITA LAPSSMKVKI IAPPERKYSV WIGGSILASL STFQQMWISK
QEYDESGPSI VHHKCF
