ID   DCUP_DROVI              Reviewed;         386 AA.
AC   O18601;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Uroporphyrinogen decarboxylase;
DE            Short=UPD;
DE            Short=URO-D;
DE            EC=4.1.1.37;
GN   Name=Urod {ECO:0000250|UniProtKB:Q9V595};
GN   Synonyms=Updo {ECO:0000250|UniProtKB:Q9V595};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Gao L., Wang S., Hickey D.A.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the decarboxylation of four acetate groups of
CC       uroporphyrinogen-III to yield coproporphyrinogen-III. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen
CC         III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57308, ChEBI:CHEBI:57309; EC=4.1.1.37;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC       {ECO:0000305}.
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DR   EMBL; U93213; AAB66372.1; -; Genomic_DNA.
DR   AlphaFoldDB; O18601; -.
DR   SMR; O18601; -.
DR   STRING; 7244.FBpp0235919; -.
DR   PRIDE; O18601; -.
DR   eggNOG; KOG2872; Eukaryota.
DR   UniPathway; UPA00251; UER00321.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00717; URO-D; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   HAMAP; MF_00218; URO_D; 1.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR   InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR   Pfam; PF01208; URO-D; 1.
DR   SUPFAM; SSF51726; SSF51726; 1.
DR   TIGRFAMs; TIGR01464; hemE; 1.
DR   PROSITE; PS00906; UROD_1; 1.
DR   PROSITE; PS00907; UROD_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Decarboxylase; Heme biosynthesis; Lyase; Porphyrin biosynthesis.
FT   CHAIN           1..386
FT                   /note="Uroporphyrinogen decarboxylase"
FT                   /id="PRO_0000187574"
FT   BINDING         44..48
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         62
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         92
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         93
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         170
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         225
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         364
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   SITE            93
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   386 AA;  43023 MW;  A119F8CC5F17DF6D CRC64;
     MTIKNNNNNN TLKHLQAFPP LKNDNLLRAA RGEVVDRVPV WVMRQAGRYL PEFQELRKQH
     DFFTVCRTPE LACEVTMQPL RRFDLDASII FSDILVIPQA LGLTVEMHAG VGPVLPQPIC
     TPEDLKRLTP DGALSRLTYV GDAITMMRHK LDGRVPLIGF TGAPWTLMGY MIEGGGSKTM
     SKAKAWLTNY PEDTKLFLIL LTDVIVDYLE MQVIAGAQML QVFESSAEHL SKEEFLLGSE
     PYLRRIRDDL VDRLTKKVIP AVPLVSSYPN NIFTLLTYLI SLLIIFAKGA GHSLKEQSEL
     GYDVIGLDWT VDPVEARAVV GPNITLQGNL DPQSMYCEPN ELRSLATEMV HKCGKSRYIA
     NVGHGITPQT PITSMEVLVE AAHNAL