ID   ACT_THELA               Reviewed;         375 AA.
AC   P10365;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Actin;
OS   Thermomyces lanuginosus (Humicola lanuginosa).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Thermomyces.
OX   NCBI_TaxID=5541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 16455 / CBS 632.91;
RX   PubMed=3362675; DOI=10.1093/nar/16.6.2553;
RA   Wildeman A.G.;
RT   "A putative ancestral actin gene present in a thermophilic eukaryote: novel
RT   combination of intron positions.";
RL   Nucleic Acids Res. 16:2553-2564(1988).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; X07463; CAA30346.1; -; Genomic_DNA.
DR   PIR; S03126; S03126.
DR   AlphaFoldDB; P10365; -.
DR   SMR; P10365; -.
DR   PRIDE; P10365; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   CHAIN           1..375
FT                   /note="Actin"
FT                   /id="PRO_0000089036"
SQ   SEQUENCE   375 AA;  41635 MW;  DBF0D1CEFDFFAEC5 CRC64;
     MEEEVAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH HGIMIGMGQK DSYVGDEAQS
     KRGVLSLRYP IEHGVVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPI NPKSNREKMT
     QIVFETFNAP AFYVSIQAVL SLYASGRTTG IVLDSGDGVT HTVPIYEGFA LTHAISRIDI
     AGRDLTDYLM KILAERGYSF TTTAEREIVR DIKEKLCYVA FDFEQELQTA AQSSTLEKSY
     ELPDGQVITI GNERFRAPEA LFNPAVLGHE SGGIHETTFN SIIKCDVDVR KDLYGNIVMS
     GGTTMYPGIA DRMQKELTAL APSSMKIKII APPERKYSVW IGGSILASLS TFQQMWVSKQ
     EYDESGPSIV HRKCF