ID   ACT_TOXGO               Reviewed;         376 AA.
AC   P53476;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Actin;
GN   Name=ACT1;
OS   Toxoplasma gondii.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX   NCBI_TaxID=5811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RH88;
RX   PubMed=9227855;
RX   DOI=10.1002/(sici)1097-0169(1997)37:3<253::aid-cm7>3.0.co;2-7;
RA   Dobrowolski J.M., Niesman I.R., Sibley L.D.;
RT   "Actin in the parasite Toxoplasma gondii is encoded by a single copy gene,
RT   ACT1 and exists primarily in a globular form.";
RL   Cell Motil. Cytoskeleton 37:253-262(1997).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; U10429; AAC13766.1; -; Genomic_DNA.
DR   AlphaFoldDB; P53476; -.
DR   SMR; P53476; -.
DR   ChEMBL; CHEMBL2424507; -.
DR   EnsemblProtists; TGME49_209030-t26_1; TGME49_209030-t26_1; TGME49_209030.
DR   VEuPathDB; ToxoDB:TGARI_209030; -.
DR   VEuPathDB; ToxoDB:TGCAST_209030; -.
DR   VEuPathDB; ToxoDB:TGCOUG_209030; -.
DR   VEuPathDB; ToxoDB:TGDOM2_209030; -.
DR   VEuPathDB; ToxoDB:TGFOU_209030; -.
DR   VEuPathDB; ToxoDB:TGGT1_209030; -.
DR   VEuPathDB; ToxoDB:TGMAS_209030; -.
DR   VEuPathDB; ToxoDB:TGME49_209030; -.
DR   VEuPathDB; ToxoDB:TGP89_209030; -.
DR   VEuPathDB; ToxoDB:TGPRC2_209030; -.
DR   VEuPathDB; ToxoDB:TGRH88_022080; -.
DR   VEuPathDB; ToxoDB:TGRUB_209030; -.
DR   VEuPathDB; ToxoDB:TGVAND_209030; -.
DR   VEuPathDB; ToxoDB:TGVEG_209030; -.
DR   OMA; FHTTAER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   CHAIN           1..376
FT                   /note="Actin"
FT                   /id="PRO_0000089044"
SQ   SEQUENCE   376 AA;  41908 MW;  FD99A0C9645779CB CRC64;
     MADEEVQALV VDNGSGNVKA GVAGDDAPRA VFPSIVGKPK NPGIMVGMEE KDCYVGDEAQ
     SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANRERM
     TQIMFETFNV PAMYVAIQAV LSLYSSGRTT GIVLDSGDGV SHTVPIYEGY ALPHAIMRLD
     LAGRDLTEYM MKILHERGYG FTTSAEKEIV RDIKEKLCYI ALDFDEEMKA AEDSSDIEKS
     YELPDGNIIT VGNERFRCPE ALFQPSFLGK EAAGVHRTTF DSIMKCDVDI RKDLYGNVVL
     SGGTTMYEGI GERLTKELTS LAPSTMKIKV VAPPERKYSV WIGGSILSSL STFQQMWITK
     EEYDESGPSI VHRKCF