ID   ACT_TRYCR               Reviewed;         376 AA.
AC   P53477;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Actin;
OS   Trypanosoma cruzi.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=5693;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DM28C;
RA   Paixao J.C., Silva R., Rondinelli E.;
RL   Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; U20234; AAA62141.1; -; Genomic_DNA.
DR   EMBL; U20234; AAA62142.1; -; Genomic_DNA.
DR   AlphaFoldDB; P53477; -.
DR   SMR; P53477; -.
DR   VEuPathDB; TriTrypDB:BCY84_19899; -.
DR   VEuPathDB; TriTrypDB:C3747_51g142; -.
DR   VEuPathDB; TriTrypDB:C4B63_38g39; -.
DR   VEuPathDB; TriTrypDB:Tc_MARK_5934; -.
DR   VEuPathDB; TriTrypDB:TcBrA4_0055380; -.
DR   VEuPathDB; TriTrypDB:TcCL_NonESM07913; -.
DR   VEuPathDB; TriTrypDB:TcCLB.510127.79; -.
DR   VEuPathDB; TriTrypDB:TcCLB.510571.30; -.
DR   VEuPathDB; TriTrypDB:TCDM_05641; -.
DR   VEuPathDB; TriTrypDB:TcG_03688; -.
DR   VEuPathDB; TriTrypDB:TCSYLVIO_008645; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0025570; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   CHAIN           1..376
FT                   /note="Actin"
FT                   /id="PRO_0000089048"
SQ   SEQUENCE   376 AA;  41903 MW;  3553CE168CBF407C CRC64;
     MSDEEQSAIV CDNGSGMVKA GFSGDDALCH VFPSIVGRPK NEQAMMGSAS KKLFVGDEAQ
     AKRGVLSLKY PIEHGIVTNW DDMEKIWHHT FYNDVRVNPE SHSVLLTEAP MNPKQNREKM
     TQIMFETFGV PAMYVGIQAV LSLYSSGRTT GIVLDAGDGV THTVPIYEGY SLPHAIRRMD
     MAGRDLTEYL MKLLMESGMT FTTSAEKEIV RNVKEQLCYV ALDFDEEVTN SAKTVNEEPF
     ELPDGTIMQV GNQRFRCPEA LFKPMLIGLD EAPGFHEMTF QSINKCDIDV RRDLYGNIVL
     SGGTTMFKNL PERLGKEISN LAPSSIKPKV VAPPERKYSV WIGGSILSSL TTFQTMWIKK
     SEYDEAGPSI VHNKCF