ID   ACU15_NEUCR             Reviewed;         926 AA.
AC   P87000; Q7S7A7; Q8X0T9;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 2.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=Transcriptional activator protein acu-15;
DE   AltName: Full=Acetate utilization protein 15;
GN   Name=acu-15; ORFNames=18A7.170, NCU06656;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=74A / STA;
RX   PubMed=12111557; DOI=10.1007/s00438-002-0682-5;
RA   Bibbins M., Crepin V.F., Cummings N.J., Mizote T., Baker K., Mellits K.H.,
RA   Connerton I.F.;
RT   "A regulator gene for acetate utilisation from Neurospora crassa.";
RL   Mol. Genet. Genomics 267:498-505(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Positive regulator of acetate induction.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: The glutamine-rich domain might function in activating gene
CC       expression.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA72324.1; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y11565; CAA72324.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL670542; CAD21506.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA31465.3; -; Genomic_DNA.
DR   PIR; T46651; T46651.
DR   RefSeq; XP_960701.3; XM_955608.3.
DR   AlphaFoldDB; P87000; -.
DR   SMR; P87000; -.
DR   STRING; 5141.EFNCRP00000006695; -.
DR   EnsemblFungi; EAA31465; EAA31465; NCU06656.
DR   GeneID; 3876849; -.
DR   KEGG; ncr:NCU06656; -.
DR   VEuPathDB; FungiDB:NCU06656; -.
DR   HOGENOM; CLU_007124_0_0_1; -.
DR   InParanoid; P87000; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   1: Evidence at protein level;
KW   Activator; Direct protein sequencing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..926
FT                   /note="Transcriptional activator protein acu-15"
FT                   /id="PRO_0000114928"
FT   DNA_BIND        24..51
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          100..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          667..801
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        607..626
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        627..649
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..701
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        721..801
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        141..152
FT                   /note="Missing (in Ref. 1; CAA72324)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        156
FT                   /note="S -> K (in Ref. 1; CAA72324)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        208..209
FT                   /note="FS -> SP (in Ref. 1; CAA72324)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        439
FT                   /note="Q -> H (in Ref. 1; CAA72324)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        498
FT                   /note="S -> P (in Ref. 1; CAA72324)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        872
FT                   /note="S -> N (in Ref. 1; CAA72324)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   926 AA;  102763 MW;  196FA11599487A97 CRC64;
     MPGILPMKVI KVGNSSQSRI AQACDRCRSK KIRCDGIRPC CSQCANVGFE CKTSDKLSRR
     AFPRGYTESL EERVRALEAE IRELKDLLDE KDEKLDMLSK MHSNRSRSAE PPRSTPAAEI
     KRDSGTPAKE DTFRVQASPL LLGVENSDSY FMGASSGRSF IETFKRKIQE NGKSCTDFNP
     EAFLHIQGCY PLSTKLAPQS MRIPPRLFSD RCVNVYFQEW APLFPVLHKP AFLRVYEEFV
     ADPEKIKNNH KLTQLYLVFS IAGLSSEQPD FQQLAACETQ WHKSLEAVLM DNTMLTLQCL
     ILALMYCTVR ADYKRLQYYK GIAVGLSHRL GLHQSQKRFS FGALTIETRK KVFWTLYTLD
     CFSAAILGLP KLLKDEDVHA EFPSDTDDEN VTEKGFQPSL PGEPTRISSA LALFRGSRIL
     GKVLEKIYPA ATSYELSLQQ MSSLEGELTE WFENLPQHLK LNFKQDKPST DVTGSRSPLL
     ALAYYYTRIL IYRPAIASSL GPKAAPALMS VAESSKSIVQ IVQLLEERSM SFSFCLNKAD
     ILIVCGMALL YQTLGLKHDS KVLKDNEKLV NSVVKIVTKV NAPGSYDFKR IAGMLVTVEE
     SLPQSLPTPP RQSPEACMPT PPAQQGSPSP SAVDRGAQPN LARQSSASLS ETDLIVQRDK
     LLGMAVTPQH QQYQHQQLQQ QHKNELSRAR SQTSFDNLRQ KAQQMRPHHR HSLSHAQVAQ
     AALMGRTSTG TQSTPNLDYL SLSSPQSPVS PVQMRSQPHQ LQQQQQQQPQ PQQQQQQHQR
     SSIASSHSQQ GQMFPQKTST GMSTAEWEAL VRSLDGGPVS LYTAIYGGPA LAPLETPSSA
     TQSSATAWGQ DPWDMSSFNL GDFVPGAPTA QSVLSLSEES ISSCDDVPSS DMGLNNGNMD
     YRNTLLPVTS AGTNNFLLDG LHGYGL