ID   ACUC_BACSU              Reviewed;         387 AA.
AC   P39067;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Acetoin utilization protein AcuC;
GN   Name=acuC; OrderedLocusNames=BSU29710;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=7934817; DOI=10.1111/j.1365-2958.1993.tb01952.x;
RA   Grundy F.J., Waters D.A., Takova T.Y., Henkin T.M.;
RT   "Identification of genes involved in utilization of acetate and acetoin in
RT   Bacillus subtilis.";
RL   Mol. Microbiol. 10:259-271(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9387221; DOI=10.1099/00221287-143-11-3431;
RA   Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.;
RT   "Sequencing and functional annotation of the Bacillus subtilis genes in the
RT   200 kb rrnB-dnaB region.";
RL   Microbiology 143:3431-3441(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: Role in growth and sporulation on acetoin or butanediol.
CC       Involved in the breakdown of these compounds used as a carbon source.
CC   -!- PATHWAY: Ketone degradation; acetoin degradation.
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. {ECO:0000305}.
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DR   EMBL; L17309; AAA68284.1; -; Genomic_DNA.
DR   EMBL; AF008220; AAC00394.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14949.1; -; Genomic_DNA.
DR   PIR; S39643; S39643.
DR   RefSeq; NP_390849.1; NC_000964.3.
DR   RefSeq; WP_004398517.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P39067; -.
DR   SMR; P39067; -.
DR   STRING; 224308.BSU29710; -.
DR   PaxDb; P39067; -.
DR   PRIDE; P39067; -.
DR   EnsemblBacteria; CAB14949; CAB14949; BSU_29710.
DR   GeneID; 936834; -.
DR   KEGG; bsu:BSU29710; -.
DR   PATRIC; fig|224308.179.peg.3229; -.
DR   eggNOG; COG0123; Bacteria.
DR   InParanoid; P39067; -.
DR   OMA; GWLRAFH; -.
DR   PhylomeDB; P39067; -.
DR   BioCyc; BSUB:BSU29710-MON; -.
DR   UniPathway; UPA00040; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   CDD; cd09994; HDAC_AcuC_like; 1.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR003085; AcuC.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01272; ACUCPROTEIN.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   3: Inferred from homology;
KW   Acetoin catabolism; Reference proteome; Sporulation.
FT   CHAIN           1..387
FT                   /note="Acetoin utilization protein AcuC"
FT                   /id="PRO_0000114729"
SQ   SEQUENCE   387 AA;  42990 MW;  DA4AE363F0973D92 CRC64;
     MRDSVFIYSP SYQTYMFHQE HPFNQQRVLL TYDLLKTINA FDDGDIVTPR LASEEELSLV
     HTDDYIQAVK LAGAGKLPAE EGESYGLGTE DTPVFAGMHE AASLLVGGTL TAADWVMSGQ
     ALHAANLGGG LHHGFRGRAS GFCIYNDSAV AIQYIQKKYS ARVLYIDTDA HHGDGVQFTF
     YDNPDVCTLS IHETGRYLFP GTGQIQEKGS GKGYGYSFNI PLDAFTEDDS FLEAYRTAAS
     EVAAYFEPDV IISQNGADAH YYDPLTHLSA TINIYEEIPR LAHTLAHQYC GGKWIAVGGG
     GYDIWRVVPR AWARIWLEMK GIDPGHEIPP EWIVKWQKQC PVALPSSWSD PADLYPPIPR
     KPEITEKNAQ TVSKALYAIR SEQQRTK