ID   ACUC_STAAN              Reviewed;         389 AA.
AC   P64376; Q99TC9;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Acetoin utilization protein AcuC;
GN   Name=acuC; OrderedLocusNames=SA1556;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=N315;
RA   Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT   "Shotgun proteomic analysis of total and membrane protein extracts of S.
RT   aureus strain N315.";
RL   Submitted (OCT-2007) to UniProtKB.
CC   -!- FUNCTION: Role in growth on acetoin or butanediol. Involved in the
CC       breakdown of these compounds used as a carbon source (By similarity).
CC       {ECO:0000250}.
CC   -!- PATHWAY: Ketone degradation; acetoin degradation.
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. {ECO:0000305}.
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DR   EMBL; BA000018; BAB42824.1; -; Genomic_DNA.
DR   PIR; C89958; C89958.
DR   RefSeq; WP_001184011.1; NC_002745.2.
DR   AlphaFoldDB; P64376; -.
DR   SMR; P64376; -.
DR   DNASU; 1124402; -.
DR   EnsemblBacteria; BAB42824; BAB42824; BAB42824.
DR   KEGG; sau:SA1556; -.
DR   HOGENOM; CLU_007727_8_0_9; -.
DR   OMA; GWLRAFH; -.
DR   UniPathway; UPA00040; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd09994; HDAC_AcuC_like; 1.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR003085; AcuC.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01272; ACUCPROTEIN.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   1: Evidence at protein level;
KW   Acetoin catabolism.
FT   CHAIN           1..389
FT                   /note="Acetoin utilization protein AcuC"
FT                   /id="PRO_0000114732"
SQ   SEQUENCE   389 AA;  44571 MW;  CA59920FC2893BFE CRC64;
     MQQHSSKTAY VYSDKLLQYR FHDQHPFNQM RLKLTTELLL NANLLSPEQI VQPRIATGDE
     LMLIHKYDYV EAIKHASHGI ISEDEAKKYG LNDEENGQFK HMHRHSATIV GGALTLADLI
     MSGKVLNGCH LGGGLHHAQP GRASGFCIYN DIAITAQYIA KEYNQRVLII DTDAHHGDGT
     QWSFYADNHV TTYSIHETGK FLFPGSGHYT ERGEDIGYGH TVNVPLEPYT EDASFLECFK
     LTVEPVVKSF KPDIILSVNG VDIHYRDPLT HLNCTLHSLY EIPYFVKYLA DSYTNGKVIM
     FGGGGYNIWR VVPRAWSHVF LSLIDQPIQS GYLPLEWINK WKHYSSELLP KRWEDRLNDY
     TYVPRTKEIS EKNKKLALHI ASWYESTRQ