ID   ACUC_STAAR              Reviewed;         389 AA.
AC   Q6GFX3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Acetoin utilization protein AcuC;
GN   Name=acuC; OrderedLocusNames=SAR1813;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Role in growth on acetoin or butanediol. Involved in the
CC       breakdown of these compounds used as a carbon source (By similarity).
CC       {ECO:0000250}.
CC   -!- PATHWAY: Ketone degradation; acetoin degradation.
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG40804.1; -; Genomic_DNA.
DR   RefSeq; WP_001183986.1; NC_002952.2.
DR   AlphaFoldDB; Q6GFX3; -.
DR   SMR; Q6GFX3; -.
DR   KEGG; sar:SAR1813; -.
DR   HOGENOM; CLU_007727_8_0_9; -.
DR   OMA; GWLRAFH; -.
DR   OrthoDB; 1443295at2; -.
DR   UniPathway; UPA00040; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd09994; HDAC_AcuC_like; 1.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR003085; AcuC.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01272; ACUCPROTEIN.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   3: Inferred from homology;
KW   Acetoin catabolism.
FT   CHAIN           1..389
FT                   /note="Acetoin utilization protein AcuC"
FT                   /id="PRO_0000114733"
SQ   SEQUENCE   389 AA;  44675 MW;  818D205AA2CD1D90 CRC64;
     MQQHLSKTAY VYSDKLLQYR FHDQHPFNQM RLKLTTELLL NANLLSPEQI VQPRIATDDE
     LMLIHKYDYV EAIKHASHGI ISEDEAMKYG LNDEENGQFK HMHRHSATIV GGALTLADLI
     MSGKALNGCH LGGGLHHAQP GRASGFCIYN DIAITAQYLA KEYNQRVLII DTDAHHGDGT
     QWSFYADNHV TTYSIHETGK FLFPGSGHYT ERGEDIGYGH TVNVPLEPYT EDSSFLECFK
     LTVEPVVKSF KPDIILSVNG VDIHYRDPLT HLNCTLHSLY EIPYFVKYLA DTYTNGKIIM
     FGGGGYNIWR VVPRAWSHVF LSLIDQPIQS GYLPLEWINK WKHYSSELLP KRWEDRLNDY
     TYVPRTKEIS EKNKKLALHI ASWYESTRQ