ID   DCUR_ECO57              Reviewed;         239 AA.
AC   P0AD02; P39271; P76794;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Transcriptional regulatory protein DcuR;
GN   Name=dcuR; OrderedLocusNames=Z5726, ECs5106;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system DcuR/DcuS.
CC       Involved in the C4-dicarboxylate-stimulated regulation of the genes
CC       encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN;
CC       dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-
CC       dicarboxylate transporter dctA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated and activated by DcuS. {ECO:0000250}.
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DR   EMBL; AE005174; AAG59323.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB38529.1; -; Genomic_DNA.
DR   PIR; B91267; B91267.
DR   PIR; G86107; G86107.
DR   RefSeq; NP_313133.1; NC_002695.1.
DR   RefSeq; WP_000611288.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AD02; -.
DR   SMR; P0AD02; -.
DR   STRING; 155864.EDL933_5470; -.
DR   EnsemblBacteria; AAG59323; AAG59323; Z5726.
DR   EnsemblBacteria; BAB38529; BAB38529; ECs_5106.
DR   GeneID; 66671965; -.
DR   GeneID; 914216; -.
DR   KEGG; ece:Z5726; -.
DR   KEGG; ecs:ECs_5106; -.
DR   PATRIC; fig|386585.9.peg.5336; -.
DR   eggNOG; COG4565; Bacteria.
DR   HOGENOM; CLU_000445_39_0_6; -.
DR   OMA; DVHGLQL; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR024187; Sig_transdc_resp-reg_cit/mal.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR45526; PTHR45526; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PIRSF; PIRSF006171; RR_citrat_malat; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..239
FT                   /note="Transcriptional regulatory protein DcuR"
FT                   /id="PRO_0000081095"
FT   DOMAIN          3..121
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        181..200
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         56
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   239 AA;  27488 MW;  4C111A0351F84FDA CRC64;
     MINVLIIDDD AMVAELNRRY VAQIPGFQCC GTASTLEKAK EIIFNSDTPI DLILLDIYMQ
     KENGLDLLPV LHNARCKSDV IVISSAADAA TIKDSLHYGV VDYLIKPFQA SRFEEALTGW
     RQKKMALEKH QYYDQAELDQ LIHGSSSNEQ DPRRLPKGLT PQTLRTLCQW IDAHQDYEFS
     TDELANEVNI SRVSCRKYLI WLVNCHILFT SIHYGVTGRP VYRYRIQAEH YSLLKQYCQ