DCUR_ECOLI
ID DCUR_ECOLI Reviewed; 239 AA.
AC P0AD01; P39271; P76794; Q2M6I0;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Transcriptional regulatory protein DcuR;
GN Name=dcuR; Synonyms=yjdG; OrderedLocusNames=b4124, JW4085;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP CHARACTERIZATION.
RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX PubMed=9765574; DOI=10.1128/jb.180.20.5421-5425.1998;
RA Zientz E., Bongaerts J., Unden G.;
RT "Fumarate regulation of gene expression in Escherichia coli by the DcuSR
RT (dcuSR genes) two-component regulatory system.";
RL J. Bacteriol. 180:5421-5425(1998).
RN [5]
RP CHARACTERIZATION.
RC STRAIN=K12 / AN387;
RX PubMed=12167640; DOI=10.1074/jbc.m204482200;
RA Janausch I.G., Garcia-Moreno I., Unden G.;
RT "Function of DcuS from Escherichia coli as a fumarate-stimulated histidine
RT protein kinase in vitro.";
RL J. Biol. Chem. 277:39809-39814(2002).
CC -!- FUNCTION: Member of the two-component regulatory system DcuR/DcuS.
CC Involved in the C4-dicarboxylate-stimulated regulation of the genes
CC encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN;
CC dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-
CC dicarboxylate transporter dctA.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated and activated by DcuS.
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DR EMBL; U14003; AAA97024.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77085.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78126.1; -; Genomic_DNA.
DR PIR; C65222; C65222.
DR RefSeq; NP_418548.1; NC_000913.3.
DR RefSeq; WP_000611288.1; NZ_STEB01000014.1.
DR AlphaFoldDB; P0AD01; -.
DR SMR; P0AD01; -.
DR BioGRID; 4261980; 12.
DR BioGRID; 852932; 1.
DR DIP; DIP-48032N; -.
DR IntAct; P0AD01; 4.
DR STRING; 511145.b4124; -.
DR iPTMnet; P0AD01; -.
DR jPOST; P0AD01; -.
DR PaxDb; P0AD01; -.
DR PRIDE; P0AD01; -.
DR EnsemblBacteria; AAC77085; AAC77085; b4124.
DR EnsemblBacteria; BAE78126; BAE78126; BAE78126.
DR GeneID; 66671965; -.
DR GeneID; 948640; -.
DR KEGG; ecj:JW4085; -.
DR KEGG; eco:b4124; -.
DR PATRIC; fig|1411691.4.peg.2576; -.
DR EchoBASE; EB2357; -.
DR eggNOG; COG4565; Bacteria.
DR HOGENOM; CLU_000445_39_0_6; -.
DR InParanoid; P0AD01; -.
DR OMA; DVHGLQL; -.
DR PhylomeDB; P0AD01; -.
DR BioCyc; EcoCyc:DCUR-MON; -.
DR PRO; PR:P0AD01; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IDA:EcoliWiki.
DR GO; GO:0001216; F:DNA-binding transcription activator activity; IDA:EcoCyc.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IDA:EcoCyc.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:EcoCyc.
DR GO; GO:0006351; P:transcription, DNA-templated; IEP:EcoCyc.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR024187; Sig_transdc_resp-reg_cit/mal.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45526; PTHR45526; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PIRSF; PIRSF006171; RR_citrat_malat; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..239
FT /note="Transcriptional regulatory protein DcuR"
FT /id="PRO_0000081094"
FT DOMAIN 3..121
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 181..200
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT MOD_RES 56
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 239 AA; 27488 MW; 4C111A0351F84FDA CRC64;
MINVLIIDDD AMVAELNRRY VAQIPGFQCC GTASTLEKAK EIIFNSDTPI DLILLDIYMQ
KENGLDLLPV LHNARCKSDV IVISSAADAA TIKDSLHYGV VDYLIKPFQA SRFEEALTGW
RQKKMALEKH QYYDQAELDQ LIHGSSSNEQ DPRRLPKGLT PQTLRTLCQW IDAHQDYEFS
TDELANEVNI SRVSCRKYLI WLVNCHILFT SIHYGVTGRP VYRYRIQAEH YSLLKQYCQ
