ID   DCUR_SHIFL              Reviewed;         239 AA.
AC   P59339;
DT   22-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2003, sequence version 1.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=Transcriptional regulatory protein DcuR;
GN   Name=dcuR; OrderedLocusNames=SF4099, S3631;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Member of the two-component regulatory system DcuR/DcuS.
CC       Involved in the C4-dicarboxylate-stimulated regulation of the genes
CC       encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN;
CC       dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-
CC       dicarboxylate transporter dctA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated and activated by DcuS. {ECO:0000250}.
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DR   EMBL; AE005674; AAN45524.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18675.1; -; Genomic_DNA.
DR   RefSeq; NP_709817.2; NC_004337.2.
DR   RefSeq; WP_000611281.1; NZ_WPGW01000256.1.
DR   AlphaFoldDB; P59339; -.
DR   SMR; P59339; -.
DR   STRING; 198214.SF4099; -.
DR   EnsemblBacteria; AAN45524; AAN45524; SF4099.
DR   EnsemblBacteria; AAP18675; AAP18675; S3631.
DR   GeneID; 1027592; -.
DR   GeneID; 58389922; -.
DR   KEGG; sfl:SF4099; -.
DR   KEGG; sfx:S3631; -.
DR   PATRIC; fig|198214.7.peg.4833; -.
DR   HOGENOM; CLU_000445_39_0_6; -.
DR   OMA; DVHGLQL; -.
DR   OrthoDB; 1755994at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR024187; Sig_transdc_resp-reg_cit/mal.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR45526; PTHR45526; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PIRSF; PIRSF006171; RR_citrat_malat; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..239
FT                   /note="Transcriptional regulatory protein DcuR"
FT                   /id="PRO_0000081097"
FT   DOMAIN          3..121
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        181..200
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         56
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   239 AA;  27458 MW;  116D7B0E3C8853A3 CRC64;
     MINVLIIDDD AMVAELNRRY VAQIPGFQCC GTASTLEKAK EIIFNSDAPI DLILLDIYMQ
     KENGLDLLPV LHNARCKSDV IVISSAADAA TIKDSLHYGV VDYLIKPFQA SRFEEALTGW
     RQKKMALEKH QYYDQAELDQ LIHGSSSNEQ DPRRLPKGLT PQTLRTLCQW IDAHQDYEFS
     TDELANEVNI SRVSCRKYLI WLVNCHILFT SIHYGVTGRP VYRYRIQAEH YSLLKQYCQ