ID   DCV1_YEAST              Reviewed;         202 AA.
AC   P43595; D6VTP2;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Protein DCV1;
DE   AltName: Full=Demands CDC28 kinase activity for viability protein 1;
DE   Flags: Precursor;
GN   Name=DCV1; OrderedLocusNames=YFR012W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7670463; DOI=10.1038/ng0795-261;
RA   Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA   Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA   Eki T.;
RT   "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT   cerevisiae.";
RL   Nat. Genet. 10:261-268(1995).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=22042866; DOI=10.1073/pnas.1115885108;
RA   Zimmermann C., Chymkowitch P., Eldholm V., Putnam C.D., Lindvall J.M.,
RA   Omerzu M., Bjoras M., Kolodner R.D., Enserink J.M.;
RT   "A chemical-genetic screen to unravel the genetic network of CDC28/CDK1
RT   links ubiquitin and Rad6-Bre1 to cell cycle progression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:18748-18753(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Leads to lethality in absence of CDC28.
CC       {ECO:0000269|PubMed:22042866}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D50617; BAA09251.1; -; Genomic_DNA.
DR   EMBL; AY557808; AAS56134.1; -; Genomic_DNA.
DR   EMBL; BK006940; DAA12452.1; -; Genomic_DNA.
DR   PIR; S56267; S56267.
DR   RefSeq; NP_116667.1; NM_001179977.1.
DR   AlphaFoldDB; P43595; -.
DR   BioGRID; 31163; 81.
DR   DIP; DIP-3935N; -.
DR   IntAct; P43595; 2.
DR   STRING; 4932.YFR012W; -.
DR   PaxDb; P43595; -.
DR   PRIDE; P43595; -.
DR   EnsemblFungi; YFR012W_mRNA; YFR012W; YFR012W.
DR   GeneID; 850565; -.
DR   KEGG; sce:YFR012W; -.
DR   SGD; S000001908; DCV1.
DR   VEuPathDB; FungiDB:YFR012W; -.
DR   HOGENOM; CLU_121101_0_0_1; -.
DR   InParanoid; P43595; -.
DR   BioCyc; YEAST:G3O-30465-MON; -.
DR   PRO; PR:P43595; -.
DR   Proteomes; UP000002311; Chromosome VI.
DR   RNAct; P43595; protein.
DR   GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR   GO; GO:0035838; C:growing cell tip; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   InterPro; IPR009571; SUR7/Rim9-like_fungi.
DR   Pfam; PF06687; SUR7; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..202
FT                   /note="Protein DCV1"
FT                   /id="PRO_0000014319"
FT   TRANSMEM        91..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   202 AA;  22435 MW;  ABBD9A01293A40AE CRC64;
     MLNYKLILLF SSFLQLISFS GFMICCLTSP IIRNWGLAQA AGVSYGTFGY CKTLNSFSCS
     RVRLIYNTSK EILPGPSLER WWLSPKARHT IGGLLISIPV ATCLTFISFA LPLVIIFLFQ
     TGGTNVSLIT SNAILHILTL LSTIFACTVI LLLCMHRDPV TISSLYDLVW LANCSLFPLL
     VIGVHFLSFR FDTSAQSDRK HS