ID   ACUK_AJECG              Reviewed;         775 AA.
AC   C0NCM1;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Transcription activator of gluconeogenesis HCBG_00867;
GN   ORFNames=HCBG_00867;
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432;
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; GG663363; EEH11412.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NCM1; -.
DR   SMR; C0NCM1; -.
DR   STRING; 447093.C0NCM1; -.
DR   EnsemblFungi; EEH11412; EEH11412; HCBG_00867.
DR   VEuPathDB; FungiDB:HCBG_00867; -.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   InParanoid; C0NCM1; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..775
FT                   /note="Transcription activator of gluconeogenesis
FT                   HCBG_00867"
FT                   /id="PRO_0000406424"
FT   DNA_BIND        77..105
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          286..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          556..592
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          649..725
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        290..326
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..351
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        557..580
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        671..710
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   775 AA;  82839 MW;  13CA9DB31A27A595 CRC64;
     MTASTQNGSP TPPPAAPTAT NQESKNMTAN PADASESQSP ANEKGSGTAE SGQKHTSTAA
     NAKDPLRPRR KKAKRACFAC QRAHLTCGDE RPCQRCIKRG LQDACHDGVR KKAKYLHDAP
     NEALMPGIRR NFYNQANATR TNANQQQNGP NSNSNKDSRQ NVAANFYSPQ SASNFDVYTQ
     AKSQQGQGHI PPTVMQDTSI NPSAFQAPSP TSTPNFDLSS NPPNRNLSSA MTQTPSSASN
     QTQDPFGAAF FDPSHPALFN FDIASMNFGN RYGALEFGML GHMATGAGDT PPSDSATQRG
     SIGRSSGTFT AQNFGDSTNT QSPFLFGDPV LNDWNPSGQS QTNPRNNNIY NQNTVAGQMG
     EQHPNAFAIE SAPMNFASPG STESPQMTTM NQFDEANAKF SSRTALMHQT NPHQPPPIST
     PGLKHQGFQV GVKRRYRSPS SIYESVKEPY SYTSGFHNLT AFIQRRFSPQ KTLQIAKALA
     SIRPSFIATT KTLNQDDLIF MEKCFQRTLW EYEDFINACG TPTIVCRRTG EIAAVGKEFS
     ILTGWKKEVL LGKEPNLNVN TGGSSPRGSG TFTPRNGNGV DPHSGMSAAG GGGGRTQPVF
     LAELLDDDSV IEFYEDFAKL AFGDSRGSVM TTCKLLKYKT KEDSAALFQG KEAQQGGSDG
     KGGGGGGDVA ATAATTSTST SNGANSSGHA NANRNNTNPK NSSPPSSSSA AAAGPLHGAQ
     LSPKQTWGKR GIAGEAGMNQ LGFRDGKVEC SYCWTVKRDV FDIPMLIVMN FLPCI