DCX_DICDI
ID DCX_DICDI Reviewed; 308 AA.
AC Q550F6;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Protein doublecortin;
DE Short=DdDCX;
GN Name=dcx; ORFNames=DDB_0217917, DDB_G0277115;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH LIS1.
RX PubMed=21034843; DOI=10.1016/j.semcdb.2010.10.007;
RA Meyer I., Kuhnert O., Graf R.;
RT "Functional analyses of lissencephaly-related proteins in Dictyostelium.";
RL Semin. Cell Dev. Biol. 22:89-96(2011).
CC -!- FUNCTION: Has a cytoskeleton-independent function in chemotactic
CC signaling during development. {ECO:0000269|PubMed:21034843}.
CC -!- SUBUNIT: Interacts with lis1. {ECO:0000269|PubMed:21034843}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:21034843}. Note=Associated with microtubules and
CC actin.
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DR EMBL; AAFI02000019; EAL69059.1; -; Genomic_DNA.
DR RefSeq; XP_642976.1; XM_637884.1.
DR AlphaFoldDB; Q550F6; -.
DR SMR; Q550F6; -.
DR STRING; 44689.DDB0233528; -.
DR PaxDb; Q550F6; -.
DR PRIDE; Q550F6; -.
DR EnsemblProtists; EAL69059; EAL69059; DDB_G0277115.
DR GeneID; 8620848; -.
DR KEGG; ddi:DDB_G0277115; -.
DR dictyBase; DDB_G0277115; dcx.
DR eggNOG; KOG3757; Eukaryota.
DR HOGENOM; CLU_035041_2_1_1; -.
DR InParanoid; Q550F6; -.
DR OMA; YICCGGE; -.
DR PRO; PR:Q550F6; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IDA:dictyBase.
DR GO; GO:0005874; C:microtubule; IDA:dictyBase.
DR GO; GO:0005815; C:microtubule organizing center; IDA:dictyBase.
DR GO; GO:0140582; P:adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway; IGI:dictyBase.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 3.10.20.230; -; 2.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR Pfam; PF03607; DCX; 2.
DR SMART; SM00537; DCX; 2.
DR SUPFAM; SSF89837; SSF89837; 2.
DR PROSITE; PS50309; DC; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Reference proteome; Repeat.
FT CHAIN 1..308
FT /note="Protein doublecortin"
FT /id="PRO_0000403668"
FT DOMAIN 21..104
FT /note="Doublecortin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT DOMAIN 194..277
FT /note="Doublecortin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT REGION 115..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..142
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 308 AA; 34321 MW; 9DB3D698D95A72D5 CRC64;
MTSTSGKPKM EKFGLQTDKS ARVILFRNGD RYHVEGVHCL VHSSKFKTFD QLKLEFSKKV
GLFTGNVQKV YSMDKKRIQD IKDFVDGHHY ICCGAEPLNT EVIPKGIQDI FGKAEVSDQD
DEPKPSKPFV SSVPPPPTPT PTSSSGTTTT SQPTLSASPS VSSAQSPKKP VVSAYKESAV
HSIDKFSVQT EKAKVIMCFR NGDRYHSGER VTVHSTKFKT YDQLKEQLSK QVKLPTGPVR
KLYLASSGKL VKTMEEIIDG EYYVCAGGET LNPLDFSPTL SEHVKQKKLQ EQQQQASEQQ
KPQEQEIF
