ID   ACUK_AJEDR              Reviewed;         779 AA.
AC   C5GF27;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Transcription activator of gluconeogenesis BDCG_02812;
GN   ORFNames=BDCG_02812;
OS   Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces
OS   dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=559297;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ER-3 / ATCC MYA-2586;
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; EQ999975; EEQ87692.1; -; Genomic_DNA.
DR   AlphaFoldDB; C5GF27; -.
DR   SMR; C5GF27; -.
DR   STRING; 559297.C5GF27; -.
DR   PRIDE; C5GF27; -.
DR   EnsemblFungi; EEQ87692; EEQ87692; BDCG_02812.
DR   VEuPathDB; FungiDB:BDCG_02812; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   OMA; VMTTCKL; -.
DR   Proteomes; UP000002039; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..779
FT                   /note="Transcription activator of gluconeogenesis
FT                   BDCG_02812"
FT                   /id="PRO_0000406426"
FT   DNA_BIND        77..105
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          135..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          202..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          559..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          655..732
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..419
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        559..588
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..731
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   779 AA;  83516 MW;  7E9A0371102D756E CRC64;
     MTASTRNGSP SPSPAAPTAT EQESKSMTTT PANPPETKSQ TNGKGSGTAQ SSQKPASTSA
     NAKDPLRPRR KKAKRACFAC QRAHLTCGDE RPCQRCIKRG LQDACHDGVR KKAKYLHDAP
     NEALLPGIRG NYYNQANTTR NIPNQRGNAS NSNSNKVSRQ SVSSANFYTP QAARSYNVYV
     QAKSQQSHVR PAVMQDASMN PSVFHAQSPS STQNFDLSSN PQTQNLSSAM SQTASSVSGQ
     NQDPFGAAFF DPSHPALFNF DIASMNFGNR YGALEFGMLG HMATGAGDTP PSDSATQRGS
     IGRSSGTFTA QNFGDSANNQ SPFLFGDPVL NDWNPTGQGQ ANPRNIYNQN AVAGQMGEQN
     PHAFAIESAP MNFASPSSTE SPQMTTTTPF DEANANFSSR TNLMHPTNTP QQSRISTPGL
     KHQGLHVGVK RRYRSPSSIY ESVKEPYSYT SGFHSLTAFI QRRFSPQKTL QIAKALASIR
     PSFIATTKTL NQDDLIFMEK CFQRTLWEYE DFINACGTPT IVCRRTGEIA AVGKEFSILT
     GWKKEVLLGK EPNLNVNTGS SLSSASSVRG SSTFTPRNNN THNSIDPHTG MPTVGGGGAS
     GRTQPVFLAE LLDDDSVIEF YEDFAKLAFG DSRGSVMTTC KLLKYKTKED SAALFHGKEE
     TQQGGVDGSS GTGTTTSGDV ATTTATGTST SNGANANTNG NNTNPNDPSS AASSSASSAL
     QGPQQSPRQT WGKRGIAGEA GMNQLGFRDG KVECSYCWTV KRDVFDIPML IVMNFLPCI